Impact of exogenous sequences on the characteristics of an epidemic type 2 recombinant vaccine-derived poliovirus

被引：25

作者：

Riquet, Franck B. ^{[1
]}

Blanchard, Claire ^{[1
]}

Jegouic, Sophie ^{[1
]}

Balanant, Jean ^{[1
]}

Guillot, Sophie ^{[1
]}

Vibet, Marie-Anne ^{[2
]}

Rakoto-Andrianarivelo, Mala ^{[3
]}

Delpeyroux, Francis ^{[1
]}

机构：

[1] Inst Pasteur, Unite Biol Virus Enter, F-75724 Paris 15, France

[2] Inst Pasteur, Unite Pharmacoepidemiol & Malad Infect, F-75724 Paris 15, France

[3] Inst Pasteur Madagascar, Unite Virol Med, Antananarivo, Madagascar

来源：

JOURNAL OF VIROLOGY | 2008年 / 82卷 / 17期

关键词：

D O I：

10.1128/JVI.00239-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Pathogenic circulating vaccine-derived polioviruses (cVDPVs) have become a major obstacle to the successful completion of the global polio eradication program. Most cVDPVs are recombinant between the oral poliovirus vaccine (OPV) and human enterovirus species C (HEV-C). To study the role of HEV-C sequences in the phenotype of cVDPVs, we generated a series of recombinants between a Madagascar cVDPV isolate and its parental OPV type 2 strain. Results indicated that the HEV-C sequences present in this cVDPV contribute to its characteristics, including pathogenicity, suggesting that interspecific recombination contributes to the phenotypic biodiversity of polioviruses and may favor the emergence of cVDPVs.

引用

页码：8927 / 8932

页数：6

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