Polyglycerols as Multi-Functional Platforms: Synthesis and Biomedical Applications

被引：30
作者：
Pouyan, Paria [1 ]
Cherri, Mariam [1 ]
Haag, Rainer [1 ]
机构：
[1] Free Univ Berlin, Inst Chem & Biochem, Takustr 3, D-14195 Berlin, Germany
来源：
POLYMERS | 2022年 / 14卷 / 13期
关键词：
linear polyglycerol; hyperbranched polyglycerol; ring-opening polymerization of glycidol; RING-OPENING POLYMERIZATION; POLYETHYLENE-GLYCOL PEG; MOLECULAR-WEIGHT; HYPERBRANCHED POLYGLYCEROLS; DENDRITIC POLYGLYCEROL; THERMORESPONSIVE NANOGELS; CATIONIC-POLYMERIZATION; POLY(ETHYLENE GLYCOL); DELIVERY-SYSTEMS; PROPYLENE-OXIDE;
D O I：
10.3390/polym14132684
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
The remarkable and unique characteristics of polyglycerols (PG) have made them an attractive candidate for many applications in the biomedical and pharmaceutical fields. The presence of multiple hydroxy groups on the flexible polyether backbone not only enables the further modification of the PG structure but also makes the polymer highly water-soluble and results in excellent biocompatibility. In this review, the polymerization routes leading to PG with different architectures are discussed. Moreover, we discuss the role of these polymers in different biomedical applications such as drug delivery systems, protein conjugation, and surface modification.
引用
收藏
页数：18
相关论文
共 122 条
[1]   Hyperbranched polyglycerols: recent advances in synthesis, biocompatibility and biomedical applications [J].
Abbina, Srinivas ;
Vappala, Sreeparna ;
Kumar, Prashant ;
Siren, Erika M. J. ;
La, Chanel C. ;
Abbasi, Usama ;
Brooks, Donald E. ;
Kizhakkedathu, Jayachandran N. .
JOURNAL OF MATERIALS CHEMISTRY B, 2017, 5 (47) :9249-9277
[2]   Point Mutation Approach to Reduce Antigenicity of Interferon Beta [J].
Abdolvahab, Mohadeseh Haji ;
Venselaar, Hanka ;
Fazeli, Ahmad ;
Arab, S. Shahriar ;
Behmanesh, Mehrdad .
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, 2020, 26 (03) :1353-1361
[3]   Use of polyglycerol (PG), instead of polyethylene glycol (PEG), prevents induction of the accelerated blood clearance phenomenon against long-circulating liposomes upon repeated administration [J].
Abu Lila, Amr S. ;
Nawata, Kosuke ;
Shimizu, Taro ;
Ishida, Tatsuhiro ;
Kiwada, Hiroshi .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2013, 456 (01) :235-242
[4]   Understanding the Interaction of Polyelectrolyte Architectures with Proteins and Biosystems [J].
Achazi, Katharina ;
Haag, Rainer ;
Ballauff, Matthias ;
Dernedde, Jens ;
Kizhakkedathu, Jayachandran N. ;
Maysinger, Dusica ;
Multhaup, Gerd .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 60 (08) :3882-3904
[5]   Lipid Nanoparticles as Delivery Systems for RNA-Based Vaccines [J].
Aldosari, Basmah N. ;
Alfagih, Iman M. ;
Almurshedi, Alanood S. .
PHARMACEUTICS, 2021, 13 (02) :1-29
[6]   Mega macromolecules as single molecule lubricants for hard and soft surfaces [J].
Anilkumar, Parambath ;
Lawson, Taylor B. ;
Abbina, Srinivas ;
Makela, Janne T. A. ;
Sabatelle, Robert C. ;
Takeuchi, Lily E. ;
Snyder, Brian D. ;
Grinstaff, Mark W. ;
Kizhakkedathu, Jayachandran N. .
NATURE COMMUNICATIONS, 2020, 11 (01)
[7]   In vivo comparative study of distinct polymeric architectures bearing a combination of paclitaxel and doxorubicin at a synergistic ratio [J].
Baabur-Cohen, Hemda ;
Vossen, Laura Isabel ;
Krueger, Harald Rune ;
Eldar-Boock, Anat ;
Yeini, Eilam ;
Landa-Rouben, Natalie ;
Tiram, Galia ;
Wedepohl, Stefanie ;
Markovsky, Ela ;
Leor, Jonathan ;
Calderon, Marcelo ;
Satchi-Fainaro, Ronit .
JOURNAL OF CONTROLLED RELEASE, 2017, 257 :118-131
[8]   Acetal-Based Functional Epoxide Monomers: Polymerizations and Applications [J].
Baek, Jinsu ;
Kim, Minseong ;
Park, Youngsin ;
Kim, Byeong-Su .
MACROMOLECULAR BIOSCIENCE, 2021, 21 (11)
[9]   Rational design of a potent, long-lasting form of interferon:: A 40 kDa branched polyethylene glycol-conjugated interferon α-2a for the treatment of hepatitis C [J].
Bailon, P ;
Palleroni, A ;
Schaffer, CA ;
Spence, CL ;
Fung, WJ ;
Porter, JE ;
Ehrlich, GK ;
Pan, W ;
Xu, ZX ;
Modi, MW ;
Farid, A ;
Berthold, W .
BIOCONJUGATE CHEMISTRY, 2001, 12 (02) :195-202
[10]   Polymersome Formation by Amphiphilic Polyglycerol-b-polydisulfide-b-polyglycerol and Glutathione-Triggered Intracellular Drug Delivery [J].
Bej, Raju ;
Achazi, Katharina ;
Haag, Rainer ;
Ghosh, Suhrit .
BIOMACROMOLECULES, 2020, 21 (08) :3353-3363
12345678910