The changing prevalence and incidence of dementia over time - current evidence

被引：502

作者：

Wu, Yu-Tzu ^{[2
]}

Beiser, Alexa S. ^{[3
]}

Breteler, Monique M. B. ^{[4
]}

Fratiglioni, Laura ^{[5
]}

Helmer, Catherine ^{[6
]}

Hendrie, Hugh C. ^{[7
]}

Honda, Hiroyuki ^{[8
]}

Ikram, M. Arfan ^{[9
]}

Langa, Kenneth M. ^{[10
,11
]}

Lobo, Antonio ^{[12
,13
]}

Matthews, Fiona E. ^{[14
]}

Ohara, Tomoyuki ^{[15
]}

peres, Karine ^{[6
]}

Qiu, Chengxuan ^{[5
]}

Seshadri, Sudha ^{[16
]}

Sjolund, Britt-Marie ^{[5
]}

Skoog, Ingmar ^{[17
]}

Brayne, Carol ^{[1
]}

机构：

[1] Univ Cambridge, Sch Clin Med, Dept Publ Hlth & Primary Care, Cambridge Inst Publ Hlth, Forvie Site,Cambridge Biomed Campus, Cambridge CB2 0SR, England

[2] Univ Exeter, Coll Life & Environm Sci, REACH Ctr Res Ageing & Cognit Hlth, Dept Psychol, Washington Singer Bldg,Perry Rd, Exeter EX4 4QG, Devon, England

[3] Boston Univ, Sch Publ Hlth, 72 East Concord St,B602 Boston, Boston, MA 02118 USA

[4] German Ctr Neurodegenerat Dis DZNE, Populat Hlth Sci, Sigmund Freud Str 27, D-53127 Bonn, Germany

[5] Stockholm Univ, Karolinska Inst, Dept Neurobiol Care Sci & Soc, Aging Res Ctr, Gavlegatan 16, S-11330 Stockholm, Sweden

[6] INSERM, Ctr INSERM, ISPED, Bordeaux Populat Hlth Res Ctr,U1219, Bordeaux, France

[7] Indiana Univ Sch Med, Dept Psychiat, 410 West 10th St, Indianapolis, IN 46202 USA

[8] Kyushu Univ, Grad Sch Med Sci, Dept Neuropathol, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan

[9] Erasmus Univ, Med Ctr, Dept Epidemiol, Wytemaweg 80, NL-3015 CN Rotterdam, Netherlands

[10] Univ Michigan, Vet Affairs Ctr Clin Management Res, Inst Social Res, Dept Internal Med, 2800 Plymouth Rd, Ann Arbor, MI 48109 USA

[11] Univ Michigan, Inst Healthcare Policy & Innovat, 2800 Plymouth Rd, Ann Arbor, MI 48109 USA

[12] Univ Zaragoza, Dept Psychiat, Madrid, Spain

[13] CIBERSAM, Inst Invest Sanitaria Aragon, Madrid, Spain

[14] Newcastle Univ, Inst Hlth & Soc, Baddiley Clark Bldg,Richardson Rd, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England

[15] Kyushu Univ, Grad Sch Med Sci, Dept Epidemiol & Publ Hlth, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan

[16] Boston Univ, Sch Med, Framingham Study, 72 East Concord St,B602 Boston, Boston, MA 02118 USA

[17] Univ Gothenburg, Inst Neurosci & Physiol, Sahlgrenska Acad, Ctr Ageing & Hlth AgeCap, Box 100, S-40530 Gothenburg, Sweden

来源：

NATURE REVIEWS NEUROLOGY | 2017年 / 13卷 / 06期

关键词：

ALZHEIMERS-DISEASE; COGNITIVE IMPAIRMENT; AFRICAN-AMERICANS; UNITED-STATES; TRENDS; POPULATION; HEALTH; PREVENTION; SUBTYPES; PERIODS;

D O I：

10.1038/nrneurol.2017.63

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Dementia is an increasing focus for policymakers, civil organizations and multidisciplinary researchers. The most recent descriptive epidemiological research into dementia is enabling investigation into how the prevalence and incidence are changing over time. To establish clear trends, such comparisons need to be founded on population-based studies that use similar diagnostic and research methods consistently over time. This narrative Review synthesizes the findings from 14 studies that investigated trends in dementia prevalence (nine studies) and incidence (five studies) from Sweden, Spain, the UK, the Netherlands, France, the USA, Japan and Nigeria. Besides the Japanese study, these studies indicate stable or declining prevalence and incidence of dementia, and some provide evidence of sex-specific changes. No single risk or protective factor has been identified that fully explains the observed trends, but major societal changes and improvements in living conditions, education and healthcare might have favourably influenced physical, mental and cognitive health throughout an individual's life course, and could be responsible for a reduced risk of dementia in later life. Analytical epidemiological approaches combined with translational neuroscientific research could provide a unique opportunity to explore the neuropathology that underlies changing occurrence of dementia in the general population.

引用

页码：327 / U79

页数：13

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