Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals

被引：145

作者：

Favre, Pauline ^{[1
,2
]}

Pauling, Melissa ^{[1
,2
]}

Stout, Jacques ^{[1
]}

Hozer, Franz ^{[1
,2
,3
,4
]}

Sarrazin, Samuel ^{[1
,2
,5
,6
]}

Abe, Christoph ^{[7
]}

Alda, Martin ^{[8
]}

Alloza, Clara ^{[9
,10
]}

Alonso-Lana, Silvia ^{[11
,12
]}

Andreassen, Ole A. ^{[13
,14
]}

Baune, Bernhard T. ^{[15
,16
]}

Benedetti, Francesco ^{[17
,18
]}

Busatto, Geraldo F. ^{[19
,20
]}

Canales-Rodriguez, Erick J. ^{[11
]}

Caseras, Xavier ^{[21
]}

Chaim-Avancini, Tiffany Moukbel ^{[19
,20
]}

Ching, Christopher R. K. ^{[22
,23
]}

Dannlowski, Udo ^{[16
]}

Deppe, Michael ^{[24
]}

Eyler, Lisa T. ^{[25
,26
]}

Fatjo-Vilas, Mar ^{[27
,28
]}

Foley, Sonya F. ^{[29
]}

Grotegerd, Dominik ^{[16
]}

Hajek, Tomas ^{[8
]}

Haukvik, Unn K. ^{[13
,14
]}

Howells, Fleur M. ^{[30
,31
]}

Jahanshad, Neda ^{[22
]}

Kugel, Harald ^{[32
]}

Lagerberg, Trine V. ^{[13
,14
]}

Lawrie, Stephen M. ^{[33
]}

Linke, Julia O. ^{[34
,35
]}

McIntosh, Andrew ^{[33
,36
]}

Melloni, Elisa M. T. ^{[37
,38
]}

Mitchell, Philip B. ^{[39
,40
]}

Polosan, Mircea ^{[41
]}

Pomarol-Clotet, Edith ^{[27
,28
]}

Repple, Jonathan ^{[16
]}

Roberts, Gloria ^{[39
,40
]}

Roos, Annerine ^{[42
]}

Rosa, Pedro G. P. ^{[19
,20
]}

Salvador, Raymond ^{[28
,29
]}

Sarro, Salvador ^{[28
,29
]}

Schofield, Peter R. ^{[43
,44
]}

Serpa, Mauricio H. ^{[17
,18
]}

Sim, Kang ^{[45
,46
,47
]}

Stein, Dan J. ^{[42
]}

Sussmann, Jess E. ^{[33
]}

Temmingh, Henk S. ^{[30
,48
]}

Thompson, Paul M. ^{[23
]}

Verdolini, Norma ^{[27
,28
,49
]}

机构：

[1] Univ Paris Saclay, CEA, Neurospin, Gif Sur Yvette, France

[2] INSERM, Unit U955, Team 15, Translat Psychiat, Creteil, France

[3] Corentin Celton Hosp, AP HP, Dept Psychiat, Issy Les Moulineaux, France

[4] Paris Descartes Univ, PRES Sorbonne Paris Cite, Paris, France

[5] Hop Univ Mondor, Pole Psychiat, DHU PePSY, Creteil, France

[6] Fondat Falret, Bipol Falret, St Ouen, France

[7] Karolinska Inst, Clin Neurosci, Stockholm, Sweden

[8] Dalhousie Univ, Dept Psychiat, Halifax, NS, Canada

[9] Univ Edinburgh, Div Psychiat, Edinburgh, Midlothian, Scotland

[10] Hosp Gen Univ Gregorio Maranon, IISGM, Dept Child & Adolescent Psychiat, Madrid, Spain

[11] FIDMAG Res Fdn, Barcelona, Spain

[12] CIBERSAM, Barcelona, Spain

[13] Univ Oslo, Dept Mental Hlth & Addict, Oslo, Norway

[14] Oslo Univ Hosp, NORMENT KG Jebsen Ctr Psychosis Res, Oslo, Norway

[15] Univ Melbourne, Dept Psychiat, Melbourne, Vic, Australia

[16] Univ Munster, Dept Psychiat, Munster, Germany

[17] Ist Sci San Raffaele, Div Neurosci, Milan, Italy

[18] Univ Vita Salute San Raffaele, Milan, Italy

[19] Univ Sao Paulo, Dept & Inst Psiquiatria, Hosp Clin HCFMUSP, Lab Psychiat Neuroimaging LIM 21,Fac Med, Sao Paulo, SP, Brazil

[20] Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, Sao Paulo, SP, Brazil

[21] Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Cardiff, S Glam, Wales

[22] Univ Calif Los Angeles, Interdept Neurosci Program, Los Angeles, CA USA

[23] Univ Southern Calif, Keck Sch Med USC, Mark & Mary Stevens Neuroimaging & Informat Inst, Imaging Genet Ctr, Los Angeles, CA 90007 USA

[24] Univ Munster, Dept Neurol, Munster, Germany

[25] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA

[26] VA San Diego Healthcare Syst, Mental Illness Res Educ & Clin Ctr, La Jolla, CA USA

[27] FIDMAG Res Fdn, Barcelona, Spain

[28] CIBERSAM, Barcelona, Spain

[29] Cardiff Univ, CUBRIC, Cardiff, S Glam, Wales

[30] Univ Cape Town, Dept Psychiat & Mental Hlth, Cape Town, South Africa

[31] Univ Cape Town, Inst Neurosci, Cape Town, South Africa

[32] Univ Munster, Inst Clin Radiol, Munster, Germany

[33] Royal Edinburgh & Associated Hosp, Dept Psychiat, Edinburgh, Midlothian, Scotland

[34] Johannes Gutenberg Univ Mainz, Dept Clin Psychol & Neuropsychol, Mainz, Germany

[35] NIMH, Emot & Dev Branch, Bethesda, MD 20892 USA

[36] Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland

[37] Sci Inst, Div Neurosci, Psychiat & Clin Psychobiol, Milan, Italy

[38] Univ Vita Salute San Raffaele, Milan, Italy

[39] Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia

[40] Black Dog Inst, Sydney, NSW, Australia

[41] Univ Grenoble Alpes, CHU Grenoble Alpes, Grenoble Inst Neurosci, INSERM,U1216, Grenoble, France

[42] Univ Cape Town, SAMRC Unit Risk & Resilience Mental Disorders, Dept Psychiat, Cape Town, South Africa

[43] Neurosci Res Australia, Sydney, NSW, Australia

[44] Univ New South Wales, Sch Med Sci, Sydney, NSW, Australia

[45] Inst Mental Hlth, West Reg, Singapore, Singapore

[46] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore

[47] Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore

[48] Valkenberg Hosp, Cape Town, South Africa

[49] Univ Barcelona, IDIBAPS, Hosp Clin, Inst Neurosci, Barcelona, Spain

[50] Hosp Sirio Libanes, Sao Paulo, SP, Brazil

来源：

NEUROPSYCHOPHARMACOLOGY | 2019年 / 44卷 / 13期

基金：

加拿大健康研究院; 英国惠康基金; 巴西圣保罗研究基金会; 欧盟地平线“2020”; 瑞典研究理事会;

关键词：

FRACTIONAL ANISOTROPY; LITHIUM; CONNECTIVITY; INTEGRITY; TRACTOGRAPHY; FEATURES; VOLUME;

D O I：

10.1038/s41386-019-0485-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Fronto-limbic white matter (WM) abnormalities are assumed to lie at the heart of the pathophysiology of bipolar disorder (BD); however, diffusion tensor imaging (DTI) studies have reported heterogeneous results and it is not clear how the clinical heterogeneity is related to the observed differences. This study aimed to identify WM abnormalities that differentiate patients with BD from healthy controls (HC) in the largest DTI dataset of patients with BD to date, collected via the ENIGMA network. We gathered individual tensor-derived regional metrics from 26 cohorts leading to a sample size of N = 3033 (1482 BD and 1551 HC). Mean fractional anisotropy (FA) from 43 regions of interest (ROI) and average whole-brain FA were entered into univariate mega- and meta-analyses to differentiate patients with BD from HC. Mega-analysis revealed significantly lower FA in patients with BD compared with HC in 29 regions, with the highest effect sizes observed within the corpus callosum (R-2 = 0.041, P-corr < 0.001) and cingulum (right: R-2 = 0.041, left: R-2 = 0.040, P-corr < 0.001). Lithium medication, later onset and short disease duration were related to higher FA along multiple ROIs. Results of the meta-analysis showed similar effects. We demonstrated widespread WM abnormalities in BD and highlighted that altered WM connectivity within the corpus callosum and the cingulum are strongly associated with BD. These brain abnormalities could represent a biomarker for use in the diagnosis of BD. Interactive three-dimensional visualization of the results is available at www.enigma-viewer.org.

引用

页码：2285 / 2293

页数：9

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