A versatile route to 2-substituted cyclic 1,3-dienes via a copper(I)-catalyzed cross-coupling reaction of dienyl triflates with Grignard reagents

被引：33

作者：

Karlström, ASE ^{[1
]}

Rönn, M ^{[1
]}

Thorarensen, A ^{[1
]}

Bäckvall, JE ^{[1
]}

机构：

[1] Uppsala Univ, Dept Organ Chem, SE-75121 Uppsala, Sweden

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1998年 / 63卷 / 08期

关键词：

D O I：

10.1021/jo971737i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general synthesis of 2-substituted cyclic 1,3-dienes in two steps from alpha,beta-unsaturated ketones has been developed. Formation of a dien-2-yl triflate followed by a copper(I)-catalyzed cross-coupling reaction with a Grignard reagent gives 2-substituted dienes in fair to excellent yields. Alkyl, aryl, and allyl Grignard reagents can be used.

引用

页码：2517 / 2522

页数：6

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