Analysis of global human gut metagenomes shows that metabolic resilience potential for short-chain fatty acid production is strongly influenced by lifestyle

被引：15

作者：

Jacobson, David K. ^{[1
,2
]}

Honap, Tanvi P. ^{[1
,2
]}

Ozga, Andrew T. ^{[3
]}

Meda, Nicolas ^{[4
]}

Kagone, Therese S. ^{[5
]}

Carabin, Helene ^{[6
,7
,8
,9
,10
]}

Spicer, Paul ^{[2
,11
]}

Tito, Raul Y. ^{[2
]}

Obregon-Tito, Alexandra J. ^{[2
]}

Reyes, Luis Marin ^{[12
]}

Troncoso-Corzo, Luzmila ^{[13
]}

Guija-Poma, Emilio ^{[14
]}

Sankaranarayanan, Krithivasan ^{[1
,15
]}

Lewis, Cecil M. ^{[1
,2
]}

机构：

[1] Univ Oklahoma, Labs Mol Anthropol & Microbiome Res, 101 David L Boren Blvd, Norman, OK 73019 USA

[2] Univ Oklahoma, Dept Anthropol, Norman, OK 73019 USA

[3] Nova Southeastern Univ, Halmos Coll Nat Sci & Oceanog, Ft Lauderdale, FL 33314 USA

[4] Minist Hlth, Ouagadougou, Burkina Faso

[5] Ctr MURAZ Res Inst, Bobo Dioulasso, Burkina Faso

[6] Univ Oklahoma, Hlth Sci Ctr, Coll Publ Hlth, Dept Biostat & Epidemiol, Oklahoma City, OK 73104 USA

[7] Univ Montreal, Fac Med Vet, Dept Pathol & Microbiol, St Hyacinthe, PQ J2S 2M2, Canada

[8] Univ Montreal, Ecole Sante Publ, Depte Med Sociale & Prevent, Montreal, PQ H3N 1X9, Canada

[9] Univ Montreal, Ctr Rech Sante Publ CReSP, Montreal, PQ H3N 1X9, Canada

[10] CIUSS Ctr Sud Montreal, Montreal, PQ H3N 1X9, Canada

[11] Univ Oklahoma, Ctr Appl Social Res, Norman, OK 73019 USA

[12] Inst Nacl Salud, Ctr Nacl Salud Publ, Lima, Peru

[13] Univ Nacl Mayor San Marcos, Fac Med, Lima, Peru

[14] Univ San Martin de Porres, Fac Med Humana, Ctr Invest Bioquim & Nutr, Lima, Peru

[15] Univ Oklahoma, Dept Microbiol & Plant Biol, Norman, OK 73019 USA

来源：

SCIENTIFIC REPORTS | 2021年 / 11卷 / 01期

基金：

美国国家科学基金会;

关键词：

MICROBIOTA; DIVERSITY; BACTERIA; DIET;

D O I：

10.1038/s41598-021-81257-w

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

High taxonomic diversity in non-industrial human gut microbiomes is often interpreted as beneficial; however, it is unclear if taxonomic diversity engenders ecological resilience (i.e. community stability and metabolic continuity). We estimate resilience through genus and species-level richness, phylogenetic diversity, and evenness in short-chain fatty acid (SCFA) production among a global gut metagenome panel of 12 populations (n=451) representing industrial and non-industrial lifestyles, including novel metagenomic data from Burkina Faso (n=90). We observe significantly higher genus-level resilience in non-industrial populations, while SCFA production in industrial populations is driven by a few phylogenetically closely related species (belonging to Bacteroides and Clostridium), meaning industrial microbiomes have low resilience potential. Additionally, database bias obfuscates resilience estimates, as we were 2-5 times more likely to identify SCFA-encoding species in industrial microbiomes compared to non-industrial. Overall, we find high phylogenetic diversity, richness, and evenness of bacteria encoding SCFAs in non-industrial gut microbiomes, signaling high potential for resilience in SCFA production, despite database biases that limit metagenomic analysis of non-industrial populations.

引用

页数：11

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