Sedimentation analysis of nanoparticle (ZrO2 and SiO2) suspensions of different particle sizes in various solvents as nanoparticle model systems was carried out using interference optics in their morphology: SiO2 particles were the analytical ultracentrifuge. The particles differed in spherical, whereas ZrO2 particles were in one case spherical and in the second case non-spherical and spherical. Different analysis programs, based on different principles of data analysis, were used for the evaluation of the size distributions of these particles, viz. SEDFIT [ls-g*(s), c(s)], Ultra Scan (vHW, 2DSA-MC), SedAnal (dcdt) and VelXLAI (GFL) method and SedAnal, in order to ascertain the benefits and limitations of these analysis methods in characterising the examined nanoparticles.