Season of birth and multiple sclerosis in Sweden

被引：27

作者：

Salzer, J. ^{[1
]}

Svenningsson, A. ^{[1
]}

Sundstrom, P. ^{[1
]}

机构：

[1] Umea Univ Hosp, Dept Neurol, SE-90187 Umea, Sweden

来源：

ACTA NEUROLOGICA SCANDINAVICA | 2010年 / 121卷 / 01期

关键词：

epidemiology; etiology; month of birth; multiple sclerosis; season of birth; seasonality; vitamin D; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; VITAMIN-D METABOLISM; RISK; PREGNANCY; WOMEN;

D O I：

10.1111/j.1600-0404.2009.01181.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective - To estimate the risk of multiple sclerosis (MS) by month of birth in Sweden. Materials and Methods - Cases (n = 9361) were obtained from the Swedish MS Registry. All births in Sweden 1900-2007 served as controls (n = 12,116,853). The risk of MS was analyzed for each month of birth separately compared with birth during the other 11 months. Results - More (11%) cases with MS than expected were born in June. Fewer (8% and 10%) cases with MS than expected were born in December and January (non-significant after correction for multiple analyses). More (5%) cases with MS than expected were born in February-July as compared with August-January. Conclusions - This study supports previous results suggesting an association between the risk of MS and the season of birth. Decreased exposure to sun in the winter leading to low vitamin D levels during pregnancy is a possible explanation that needs further research.

引用

页码：20 / 23

页数：4

共 23 条

[21] Seasonal variation of nutrient intake in pregnancy: effects on infant measures and possible influence on diseases related to season of birth [J].