Season of birth and multiple sclerosis in Sweden

被引：27
作者：
Salzer, J. [1 ]
Svenningsson, A. [1 ]
Sundstrom, P. [1 ]
机构：
[1] Umea Univ Hosp, Dept Neurol, SE-90187 Umea, Sweden
来源：
ACTA NEUROLOGICA SCANDINAVICA | 2010年 / 121卷 / 01期
关键词：
epidemiology; etiology; month of birth; multiple sclerosis; season of birth; seasonality; vitamin D; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; VITAMIN-D METABOLISM; RISK; PREGNANCY; WOMEN;
D O I：
10.1111/j.1600-0404.2009.01181.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Objective - To estimate the risk of multiple sclerosis (MS) by month of birth in Sweden. Materials and Methods - Cases (n = 9361) were obtained from the Swedish MS Registry. All births in Sweden 1900-2007 served as controls (n = 12,116,853). The risk of MS was analyzed for each month of birth separately compared with birth during the other 11 months. Results - More (11%) cases with MS than expected were born in June. Fewer (8% and 10%) cases with MS than expected were born in December and January (non-significant after correction for multiple analyses). More (5%) cases with MS than expected were born in February-July as compared with August-January. Conclusions - This study supports previous results suggesting an association between the risk of MS and the season of birth. Decreased exposure to sun in the winter leading to low vitamin D levels during pregnancy is a possible explanation that needs further research.
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页码：20 / 23
页数：4
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