Reassessment of long circulation via monitoring of integral polymeric nanoparticles justifies a more accurate understanding

被引：58

作者：

He, Haisheng ^{[1
,2
]}

Jiang, Sifan ^{[3
]}

Xie, Yunchang ^{[1
,2
]}

Lu, Yi ^{[1
,2
]}

Qi, Jianping ^{[1
,2
]}

Dong, Xiaochun ^{[1
,2
]}

Zhao, Weili ^{[1
,2
,4
]}

Yin, Zongning ^{[3
]}

Wu, Wei ^{[1
,2
]}

机构：

[1] Fudan Univ, Sch Pharm, Key Lab Smart Drug Delivery, MOE, Shanghai 201203, Peoples R China

[2] Fudan Univ, Sch Pharm, PLA, Shanghai 201203, Peoples R China

[3] Sichuan Univ, West China Sch Pharm, Chengdu 610041, Sichuan, Peoples R China

[4] Henan Univ, Minist Educ, Key Lab Special Funct Mat, Kaifeng 475001, Peoples R China

来源：

NANOSCALE HORIZONS | 2018年 / 3卷 / 04期

基金：

中国国家自然科学基金;

关键词：

PEG CHAIN-LENGTH; PEGYLATED LIPOSOMAL DOXORUBICIN; SOLID LIPID NANOPARTICLES; POLYETHYLENE-GLYCOL PEG; IN-VIVO EVALUATION; DRUG-DELIVERY; PHAGOCYTIC UPTAKE; PARTICLE-SIZE; LOADED PLGA; STEALTH NANOPARTICLES;

D O I：

10.1039/c8nh00010g

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Monitoring of payloads results in a biased perception of long circulation of nanoparticles. Instead, herein, the long-circulation effect was re-confirmed by monitoring integral nanoparticles, but circulation was not found to be as long as generally perceived. In contrast, disparate pharmacokinetics were obtained by monitoring a model drug, paclitaxel, highlighting the bias of the conventional protocol.

引用

页码：397 / 407

页数：11

共 60 条

[1] Liposomal drug delivery systems: From concept to clinical applications [J].

Allen, Theresa M. ;

Cullis, Pieter R. .

ADVANCED DRUG DELIVERY REVIEWS, 2013, 65 (01) :36-48

[2] Formulation and Evaluation of Paclitaxel-Loaded Polymeric Nanoparticles Composed of Polyethylene Glycol and Polylactic Acid Block Copolymer [J].

Araki, Tomoya ;

Kono, Yusuke ;

Ogawara, Ken-ichi ;

Watanabe, Takaichi ;

Ono, Tsutomu ;

Kimura, Toshikiro ;

Higaki, Kazutaka .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2012, 35 (08) :1306-1313

[3] Design attributes of long-circulating polymeric drug delivery vehicles [J].

Beck-Broichsitter, Moritz ;

Nicolas, Julien ;

Couvreur, Patrick .

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2015, 97 :304-317

[4] Preparation, characterization, in vivo biodistribution and pharmacokinetic studies of donepezil-loaded PLGA nanoparticles for brain targeting [J].

Bhavna ;

Md, Shadab ;

Ali, Mushir ;

Baboota, Sanjula ;

Sahni, Jasjeet Kaur ;

Bhatnagar, Aseem ;

Ali, Javed .

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2014, 40 (02) :278-287

[5] Size Dependent Biodistribution and SPECT Imaging of 111In-Labeled Polymersomes [J].

Brinkhuis, Rene P. ;

Stojanov, Katica ;

Laverman, Peter ;

Eilander, Jos ;

Zuhorn, Inge S. ;

Rutjes, Floris P. J. T. ;

van Hest, Jan C. M. .

BIOCONJUGATE CHEMISTRY, 2012, 23 (05) :958-965

[6]

Cabral H, 2011, NAT NANOTECHNOL, V6, P815, DOI [10.1038/NNANO.2011.166, 10.1038/nnano.2011.166]

[7] Degradability and Clearance of Silicon, Organosilica, Silsesquioxane, Silica Mixed Oxide, and Mesoporous Silica Nanoparticles [J].

Croissant, Jonas G. ;

Fatieiev, Yevhen ;

Khashab, Niveen M. .

ADVANCED MATERIALS, 2017, 29 (09)

[8] Paclitaxel-loaded micelles enhance transvascular permeability and retention of nanomedicines in tumors [J].

Danhier, Fabienne ;

Danhier, Pierre ;

De Saedeleer, Christophe J. ;

Fruytier, Anne-Catherine ;

Schleich, Nathalie ;

Rieux, Anne des ;

Sonveaux, Pierre ;

Gallez, Bernard ;

Preat, Veronique .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2015, 479 (02) :399-407

[9] Spleen capture of nanoparticles: Influence of animal species and surface characteristics [J].

Demoy, M ;

Andreux, JP ;

Weingarten, C ;

Gouritin, B ;

Guilloux, V ;

Couvreur, P .

PHARMACEUTICAL RESEARCH, 1999, 16 (01) :37-41

[10]

Fang Chao, 2006, Yaoxue Xuebao, V41, P305

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