Risk factors for treatment related clinical fluctuations in Guillain-Barre Syndrome

被引:43
|
作者
Visser, LH
van der Meché, FGA
Meulstee, J
van Doorn, PA
机构
[1] Erasmus MC, Dept Neurol, Rotterdam, Netherlands
[2] St Elizabeth Hosp, Dept Neurol, Tilburg, Netherlands
来源
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 1998年 / 64卷 / 02期
关键词
Guillain-Barre syndrome; risk factors; treatment related fluctuations; treatment;
D O I
10.1136/jnnp.64.2.242
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The risk factors for treatment related clinical fluctuations, relapses occurring after initial therapeutic induced stabilisation or improvement, were evaluated in a group of 172 patients with Guillain-Barre syndrome. Clinical, laboratory, and electrodiagnostic features of all 16 patients with Guillain-Barre syndrome with treatment related fluctuations, of whom 13 were retreated, were compared with those who did not have fluctuations. No significant differences were found between patients with Guillain-Barre syndrome treated with plasma exchange and patients treated with intravenous immune globulins either alone or in combination With high dose methylprednisolone. None of the patients with Guillain-Barre syndrome with preceding gastrointestinal illness, initial predominant distal weakness, acute motor neuropathy, or anti-GM1 antibodies showed treatment related fluctuations, On the other hand patients with fluctuations showed a trend to have the fluctuations after a protracted disease course. It is therefore suggested that treatment related clinical fluctuations are due to a more prolonged immune attack. There is no indication that the fluctuations are related to treatment modality. The results of this study may help the neurologist to identify patients with Guillain-Barre syndrome who are at risk for treatment related fluctuations.
引用
收藏
页码:242 / 244
页数:3
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