A water-soluble thiophene-croconaine dye with a high molar extinction coefficient for NIR fluorescence imaging-guided synergistic photothermal/photodynamic therapy of cancer

被引：13

作者：

Pang, E. ^{[1
]}

Huang, Rong ^{[1
]}

Zhao, Shaojing ^{[1
]}

Yang, Ke ^{[1
]}

Li, Baoling ^{[1
]}

Tan, Qiuxia ^{[1
]}

Tan, Siyi ^{[2
]}

Lan, Minhuan ^{[1
]}

Wang, Benhua ^{[1
]}

Song, Xiangzhi ^{[1
]}

机构：

[1] Cent South Univ, Coll Chem & Chem Engn, Hunan Prov Key Lab Micro & Nano Mat Interface Sci, Changsha, Peoples R China

[2] Huazhi Med Lab Co Ltd, 618 Heping Rd, Changsha 410125, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2022年 / 10卷 / 47期

基金：

中国国家自然科学基金;

关键词：

NANOPARTICLES;

D O I：

10.1039/d2tb01772e

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Phototherapeutic agents with near-infrared (NIR) fluorescence, strong reactive oxygen species generation and photothermal conversion capabilities are highly desirable for use in cancer therapy. Herein, a water-soluble NIR croconaine dye (TCR) with a thiophene-croconaine rigid core and two symmetric alkyl chains was designed and synthesized. TCR exhibits intense NIR absorption and fluorescence that peaked at 780 and 815 nm, respectively, with a high molar extinction coefficient of 1.19 x 10(5) M-1 cm(-1). Moreover, TCR has a high photothermal conversion efficiency of 77% and is capable of generating hydroxyl radicals (OH center dot) under 735 nm laser irradiation. Based on these outstanding properties, TCR has proven its application in NIR fluorescence imaging-guided synergistic photothermal/photodynamic therapy of cancer.

引用

页码：9848 / 9854

页数：7

共 28 条

[1] Platinum-doped carbon nanoparticles inhibit cancer cell migration under mild laser irradiation: Multi-organelle-targeted photothermal therapy [J].

Bao, Yan-Wen ;

Hua, Xian-Wu ;

Chen, Xiaokai ;

Wu, Fu-Gen .

BIOMATERIALS, 2018, 183 :30-42

[2] Pt@polydopamine nanoparticles as nanozymes for enhanced photodynamic and photothermal therapy [J].

Cao, Hongqian ;

Yang, Yang ;

Liang, Minghui ;

Ma, Yuntian ;

Sun, Nan ;

Gao, Xibao ;

Li, Junbai .

CHEMICAL COMMUNICATIONS, 2021, 57 (02) :255-258

[3] Albumin-NIR dye self-assembled nanoparticles for photoacoustic pH imaging and pH-responsive photothermal therapy effective for large tumors [J].

Chen, Qian ;

Liu, Xiaodong ;

Zeng, Jianfeng ;

Cheng, Zhenping ;

Liu, Zhuang .

BIOMATERIALS, 2016, 98 :23-30

[4] Multi-Functional Liposome: A Powerful Theranostic Nano-Platform Enhancing Photodynamic Therapy [J].

Cheng, Xiamin ;

Gao, Jing ;

Ding, Yang ;

Lu, Yao ;

Wei, Qiancheng ;

Cui, Dezhi ;

Fan, Jiali ;

Li, Xiaoman ;

Zhu, Ershu ;

Lu, Yongna ;

Wu, Qiong ;

Li, Lin ;

Huang, Wei .

ADVANCED SCIENCE, 2021, 8 (16)

[5] Near-Infrared Hypocrellin Derivatives for Synergistic Photodynamic and Photothermal Therapy [J].

Ding, Ying ;

Liu, Weimin ;

Wu, Jiasheng ;

Zheng, Xiuli ;

Ge, Jiechao ;

Ren, Haohui ;

Zhang, Wenjun ;

Lee, Chun-Sing ;

Wang, Pengfei .

CHEMISTRY-AN ASIAN JOURNAL, 2020, 15 (21) :3462-3468

[6] Croconaine rotaxane for acid activated photothermal heating and ratiometric photoacoustic imaging of acidic pH [J].

Guha, Samit ;

Shaw, Gillian Karen ;

Mitcham, Trevor M. ;

Bouchard, Richard R. ;

Smith, Bradley D. .

CHEMICAL COMMUNICATIONS, 2016, 52 (01) :120-123

[7] A Porphyrin-Based Conjugated Polymer for Highly Efficient In Vitro and In Vivo Photothermal Therapy [J].

Guo, Bing ;

Feng, Guangxue ;

Manghnani, Purnima Naresh ;

Cai, Xiaolei ;

Liu, Jie ;

Wu, Wenbo ;

Xu, Shidang ;

Cheng, Xiamin ;

Teh, Cathleen ;

Liu, Bin .

SMALL, 2016, 12 (45) :6243-6254

[8] Heavy-Atom-Modulated Supramolecular Assembly Increases Antitumor Potency against Malignant Breast Tumors via Tunable Cooperativity [J].

Guo, Zhengqing ;

He, Hui ;

Zhang, Yi ;

Rao, Jiaming ;

Yang, Tao ;

Li, Ting ;

Wang, Lu ;

Shi, Mengke ;

Wang, Mengya ;

Qiu, Shihong ;

Song, Xue ;

Ke, Hengte ;

Chen, Huabing .

ADVANCED MATERIALS, 2021, 33 (02)

[9] A Sequential Dual-Model Strategy Based on Photoactivatable Metallopolymer for On-Demand Release of Photosensitizers and Anticancer Drugs [J].

He, Maomao ;

He, Guangli ;

Wang, Peiyuan ;

Jiang, Suhua ;

Jiao, Ziyue ;

Xi, Dongmei ;

Miao, Pengcheng ;

Leng, Xuefei ;

Wei, Zhiyong ;

Li, Yang ;

Yang, Yanjun ;

Wang, Ran ;

Du, Jianjun ;

Fan, Jiangli ;

Sun, Wen ;

Peng, Xiaojun .

ADVANCED SCIENCE, 2021, 8 (23)

[10] Photosensitizers for Photodynamic Therapy [J].

Lan, Minhuan ;

Zhao, Shaojing ;

Liu, Weimin ;

Lee, Chun-Sing ;

Zhang, Wenjun ;

Wang, Pengfei .

ADVANCED HEALTHCARE MATERIALS, 2019, 8 (13)

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