Tumor-Associated Carbohydrate Antigens Targeting Immunotherapy

被引:3
作者
Matsumoto, Yasuyuki [1 ]
机构
[1] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA
关键词
Tumor-associated carbohydrate antigens (TACAs); Tn antigen; Diagnostic biomarker; Cancer immunotherapy; Tumor microenvironment (TME); O-GLYCOSYLATION; CANCER METASTASIS; TN-ANTIGEN; EXPRESSION; GLYCANS; CELLS; IMMUNOGLOBULIN; GLYCOPEPTIDES; GLYCOPROTEOME; PPGALNAC-T13;
D O I
10.4052/tigg.2009.1E
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Tumor-associated carbohydrate antigens (TACAs) are expressed in a majority of carcinoma-type malignancies, but not in normal tissue, and they play an important role in driving oncogenic transformation. A highly relevant TACA is the Tn antigen, which is ubiquitously expressed in many human carcinomas, and which likely represents a promising diagnostic biomarker and candidate for molecular-targeted therapy. Over the last several decades, a myriad of immunotherapies and vaccination therapies against the Tn antigen have been developed; however, these have not shown sufficient anti-tumor efficacy. This review presents a novel methodology for generating a defined anti-Tn monoclonal antibody (mAb) and presents the latest cancer immunotherapies with anti-Tn mAb (targeted therapy, CAR-T cell therapy, and antibody-drug conjugates) within the hostile tumor microenvironment.
引用
收藏
页码:E33 / E38
页数:6
相关论文
共 50 条
[41]   Targeting tumor-associated macrophages for cancer treatment [J].
Li, Mengjun ;
He, Linye ;
Zhu, Jing ;
Zhang, Peng ;
Liang, Shufang .
CELL AND BIOSCIENCE, 2022, 12 (01)
[42]   Evaluation of a panel of tumor-associated antigens in breast cancer [J].
Pagaza-Straffon, Cecilia ;
Marchat, Laurence A. ;
Herrera, Luis ;
Diaz-Chavez, Jose ;
Gonzalez Avante, Mauricio ;
Palacios Rodriguez, Yadira ;
Castanon Arreola, Mauricio ;
Lopez-Camarillo, Cesar .
CANCER BIOMARKERS, 2020, 27 (02) :207-211
[43]   Autoantibodies to tumor-associated antigens in lung cancer diagnosis [J].
Zhang, Xiuzhi ;
Liu, Man ;
Zhang, Xue ;
Wang, Yulin ;
Dai, Liping .
ADVANCES IN CLINICAL CHEMISTRY, VOL 103, 2021, 103 :1-45
[44]   Synthetic Vaccines from Tumor-Associated Glycopeptide Antigens [J].
Westerlind, Ulrike ;
Kunz, Horst .
CHIMIA, 2011, 65 (1-2) :30-34
[45]   Harnessing tumor-associated macrophages as aids for cancer immunotherapy [J].
Li, Xiaolei ;
Liu, Rui ;
Su, Xiao ;
Pan, Yongsha ;
Han, Xiaofeng ;
Shao, Changshun ;
Shi, Yufang .
MOLECULAR CANCER, 2019, 18 (01)
[46]   The Metabolic Features of Tumor-Associated Macrophages: Opportunities for Immunotherapy? [J].
Mojsilovic, Sonja S. ;
Mojsilovic, Slavko ;
Villar, Victor H. ;
Santibanez, Juan F. .
ANALYTICAL CELLULAR PATHOLOGY, 2021, 2021
[47]   Role of Tumor-Associated Macrophages in Breast Cancer Immunotherapy [J].
He, Yan ;
Liu, Quan ;
Luo, Zhihao ;
Hu, Qian ;
Wang, Li ;
Guo, Zifen .
FRONTIERS IN BIOSCIENCE-LANDMARK, 2025, 30 (04)
[48]   Targeting CAMKII to reprogram tumor-associated macrophages and inhibit tumor cells for cancer immunotherapy with an injectable hybrid peptide hydrogel [J].
Dai, Xiaomeng ;
Meng, Jingshu ;
Deng, Suke ;
Zhang, Lingling ;
Wan, Chao ;
Lu, Lisen ;
Huang, Jing ;
Hu, Yan ;
Zhang, Zhanjie ;
Li, Yan ;
Lovell, Jonathan F. ;
Wu, Gang ;
Yang, Kunyu ;
Jin, Honglin .
THERANOSTICS, 2020, 10 (07) :3049-3063
[49]   Cytotoxic T Lymphocytes Simultaneously Targeting Multiple Tumor-associated Antigens to Treat EBV Negative Lymphoma [J].
Gerdemann, Ulrike ;
Katari, Usha ;
Christin, Anne S. ;
Cruz, Conrad R. ;
Tripic, Tamara ;
Rousseau, Alexandra ;
Gottschalk, Stephen M. ;
Savoldo, Barbara ;
Vera, Juan F. ;
Heslop, Helen E. ;
Brenner, Malcolm K. ;
Bollard, Catherine M. ;
Rooney, Cliona M. ;
Leen, Ann M. .
MOLECULAR THERAPY, 2011, 19 (12) :2258-2268
[50]   Targeting IRG1 reverses the immunosuppressive function of tumor-associated macrophages and enhances cancer immunotherapy [J].
Chen, Yu-Jia ;
Li, Guan-Nan ;
Li, Xian-Jing ;
Wei, Lin -Xing ;
Fu, Min-Jie ;
Cheng, Zhou-Li ;
Yang, Zhen ;
Zhu, Gui-Qi ;
Wang, Xu-Dong ;
Zhang, Cheng ;
Zhang, Jin-Ye ;
Sun, Yi-Ping ;
Saiyin, Hexige ;
Zhang, Jin ;
Liu, Wei-Ren ;
Zhu, Wen -Wei ;
Guan, Kun-Liang ;
Xiong, Yue ;
Yang, Yong ;
Ye, Dan ;
Chen, Lei-Lei .
SCIENCE ADVANCES, 2023, 9 (17)