Tumor-Associated Carbohydrate Antigens Targeting Immunotherapy

被引：4
作者：
Matsumoto, Yasuyuki [1 ]
机构：
[1] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA
来源：
TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY | 2021年 / 33卷 / 192期
关键词：
Tumor-associated carbohydrate antigens (TACAs); Tn antigen; Diagnostic biomarker; Cancer immunotherapy; Tumor microenvironment (TME); O-GLYCOSYLATION; CANCER METASTASIS; TN-ANTIGEN; EXPRESSION; GLYCANS; CELLS; IMMUNOGLOBULIN; GLYCOPEPTIDES; GLYCOPROTEOME; PPGALNAC-T13;
D O I：
10.4052/tigg.2009.1E
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Tumor-associated carbohydrate antigens (TACAs) are expressed in a majority of carcinoma-type malignancies, but not in normal tissue, and they play an important role in driving oncogenic transformation. A highly relevant TACA is the Tn antigen, which is ubiquitously expressed in many human carcinomas, and which likely represents a promising diagnostic biomarker and candidate for molecular-targeted therapy. Over the last several decades, a myriad of immunotherapies and vaccination therapies against the Tn antigen have been developed; however, these have not shown sufficient anti-tumor efficacy. This review presents a novel methodology for generating a defined anti-Tn monoclonal antibody (mAb) and presents the latest cancer immunotherapies with anti-Tn mAb (targeted therapy, CAR-T cell therapy, and antibody-drug conjugates) within the hostile tumor microenvironment.
引用
收藏
页码：E33 / E38
页数：6
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