Iron metabolism and iron supplementation in cancer patients (vol 127, pg 907, 2015)

被引：4

作者：

Ludwig, Heinz ^{[1
]}

Evstatiev, Rayko ^{[2
]}

Kornek, Gabriela ^{[3
]}

Aapro, Matti ^{[4
]}

Bauernhofer, Thomas ^{[5
]}

Buxhofer-Ausch, Veronika ^{[6
]}

Fridrik, Michael ^{[7
]}

Geissler, Dietmar

Geissler, Klaus ^{[8
,9
]}

Gisslinger, Heinz ^{[3
]}

Koller, Elisabeth ^{[10
]}

Kopetzky, Gerhard ^{[11
]}

Lang, Alois ^{[12
]}

Rumpold, Holger ^{[13
]}

Steurer, Michael ^{[14
]}

Kamali, Houman ^{[15
]}

Link, Hartmut ^{[16
]}

机构：

[1] Wilhelminenspital Stadt Wien, Wilhelminen Krebsforsch Inst, Zentrum Onkol, Med Abt 1, A-1160 Vienna, Austria

[2] MedUni, Univ Klin Innere Med 3, Vienna, Austria

[3] MedUni, Univ Klin Innere Med 1, Vienna, Austria

[4] Clin Genolier, Inst Multidisciplinaire Oncol, Genolier, Switzerland

[5] MedUni, Univ Klin Innere Med, Graz, Austria

[6] KH Elisabethinen, Abt Interne 1, Linz, Austria

[7] AKH, Abt Interne 3, Linz, Austria

[8] Klinikum Klagenfurt, Med Abt 1, Klagenfurt, Austria

[9] Krankenhaus Hietzing, Med Abt 5, Vienna, Austria

[10] Hanusch Hosp, Med Abt 3, Vienna, Austria

[11] Landesklinikum St Polten, Med Abt 1, Polten, Austria

[12] Landeskrankenhaus Feldkirch, Innere Med Abt, Feldkirch, Austria

[13] Krankenhaus Barmherzigen, Abt Interne 1, Linz, Austria

[14] MedUni Innsbruck, Univ Klin Innere Med 5, Innsbruck, Austria

[15] Bristol Myers Squibb, Vienna, Austria

[16] Westpfalz Klinikum, Med Klin 1, Kaiserslautern, Germany

来源：

WIENER KLINISCHE WOCHENSCHRIFT | 2015年 / 127卷 / 23-24期

关键词：

Functional and absolute iron deficiency; Iron deficiency; Iron supplementation; Recommendations for clinical practice; Tumor anemia;

D O I：

10.1007/s00508-015-0893-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Iron deficiency and iron deficiency-associated anemia are common complications in cancer patients. Most iron deficient cancer patients present with functional iron deficiency (FID), a status with adequate storage iron, but insufficient iron supply for erythroblasts and other iron dependent tissues. FID is the consequence of the cancer-associated cytokine release, while in absolute iron deficiency iron stores are depleted resulting in similar but often more severe symptoms of insufficient iron supply. Here we present a short review on the epidemiology, pathophysiology, diagnosis, clinical symptoms, and treatment of iron deficiency in cancer patients. Special emphasis is given to intravenous iron supplementation and on the benefits and limitations of different formulations. Based on these considerations and recommendations from current international guidelines we developed recommendations for clinical practice and classified the level of evidence and grade of recommendation according to the principles of evidence-based medicine.

引用

页码：920 / 921

页数：2