Functional synthetic probes for selective targeting and multi-analyte detection and imaging (vol 48, pg 4155, 2019)

被引:16
作者
Yue, Yongkang [1 ]
Huo, Fangjun [2 ]
Cheng, Fangqin [3 ]
Zhu, Xijing [4 ]
Mafireyi, Tendai [4 ]
Strongin, Robert M. [4 ]
Yin, Caixia [1 ]
机构
[1] Shanxi Univ, Key Lab Mat Energy Convers & Storage Shanxi Prov, Key Lab Chem Biol & Mol Engn, Minist Educ,Inst Mol Sci, Taiyuan 030006, Shanxi, Peoples R China
[2] Shanxi Univ, Res Inst Appl Chem, Taiyuan 030006, Shanxi, Peoples R China
[3] Shanxi Univ, Inst Resources & Environm Engn, Taiyuan 030006, Shanxi, Peoples R China
[4] Portland State Univ, Dept Chem, Portland, OR 97201 USA
基金
中国国家自然科学基金; 山西省青年科学基金;
关键词
D O I
10.1039/c9cs90059d
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
In contrast to the classical design of a probe with one binding site to target one specific analyte, probes with multiple interaction sites or, alternatively, with single sites promoting tandem reactions to target one or multiple analytes, have been developed. They have been used in addressing the inherent challenges of selective targeting in the presence of structurally similar compounds and in complex matrices, as well as the visualization of the in vivo interaction or crosstalk between the analytes. Examples of analytes include reactive sulfur species, reactive oxygen species, nucleotides and enzymes. This review focuses on recent innovations in probe design, detection mechanisms and the investigation of biological processes. The vision is to promote the ongoing development of fluorescent probes to enable deeper insight into the physiology of bioactive analytes. © 2019 The Royal Society of Chemistry.
引用
收藏
页码:4336 / 4337
页数:2
相关论文
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[1]   A dual-function fluorescent probe for monitoring the degrees of hypoxia in living cells via the imaging of nitroreductase and adenosine triphosphate [J].
Fang, Yu ;
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Ma, Huimin .
CHEMICAL COMMUNICATIONS, 2018, 54 (43) :5454-5457
[2]  
Yue YK, 2019, CHEM SOC REV, V48, P4155, DOI 10.1039/c8cs01006d