Medication Effects on Sleep and Breathing

被引：40

作者：

Seda, Gilbert ^{[1
]}

Tsai, Sheila ^{[2
]}

Lee-Chiong, Teofilo ^{[3
]}

机构：

[1] Naval Med Ctr San Diego, Dept Pulm & Sleep Med, San Diego, CA 92134 USA

[2] Natl Jewish Hlth, Div Pulm Crit Care & Sleep Med, Denver, CO 80206 USA

[3] Univ Colorado, Natl Jewish Hlth, Div Pulm & Crit Care Med, Denver, CO 80206 USA

来源：

CLINICS IN CHEST MEDICINE | 2014年 / 35卷 / 03期

关键词：

Obstructive sleep apnea; Central sleep apnea; Hypnotics; Benzodiazepines; Antipsychotics; Estrogen; Progesterone; Testosterone; POSITIVE AIRWAY PRESSURE; NOCTURNAL OXYGEN DESATURATION; DOXEPIN; MG; APNEA SYNDROME; DOUBLE-BLIND; VENTILATORY RESPONSE; MEDROXYPROGESTERONE ACETATE; TESTOSTERONE THERAPY; RESPIRATORY-FAILURE; OUTPATIENT TRIAL;

D O I：

10.1016/j.ccm.2014.06.011

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Sleep respiration is regulated by circadian, endocrine, mechanical and chemical factors, and characterized by diminished ventilatory drive and changes in Pao(2) and Paco(2) thresholds. Hypoxemia and hypercapnia are more pronounced during rapid eye movement. Breathing is influenced by sleep stage and airway muscle tone. Patient factors include medical comorbidities and body habitus. Medications partially improve obstructive sleep apnea and stabilize periodic breathing at altitude. Potential adverse consequences of medications include precipitation or worsening of disorders. Risk factors for adverse medication effects include aging, medical disorders, and use of multiple medications that affect respiration.

引用

页码：557 / +

页数：14

共 137 条

[1] DIPHENHYDRAMINE ENHANCES THE INTERACTION OF HYPERCAPNIC AND HYPOXIC VENTILATORY DRIVE [J].

ALEXANDER, CM ;

SEIFERT, HA ;

BLOUIN, RT ;

CONARD, PF ;

GROSS, JB .

ANESTHESIOLOGY, 1994, 80 (04) :789-795

[2]

ATKINSON RL, 1985, INT J OBESITY, V9, P233

[3] Diphenhydramine increases ventilatory drive during alfentanil infusion [J].

Babenco, HD ;

Blouin, RT ;

Conard, PF ;

Gross, JB .

ANESTHESIOLOGY, 1998, 89 (03) :642-647

[4]

Batoon SB, 2001, J AM GERIATR SOC, V49, P498

[5] Effects of zolpidem and zaleplon on sleep, respiratory patterns and performance at a simulated altitude of 4,000 m [J].

Beaumont, M ;

Batéjat, D ;

Coste, O ;

van Beers, P ;

Colas, A ;

Clère, JM ;

Piérard, C .

NEUROPSYCHOBIOLOGY, 2004, 49 (03) :154-162

[6] Zaleplon and zolpidem objectively alleviate sleep disturbances in mountaineers at a 3,613 meter altitude [J].

Beaumont, Maurice ;

Batejat, Denise ;

Pierard, Christophe ;

Van Beers, Pascal ;

Philippe, Matthieu ;

Leger, Damien ;

Savourey, Gustave ;

Jouanin, Jean-Claude .

SLEEP, 2007, 30 (11) :1527-1533

[7] EFFECT OF ETHANOL ON THE AROUSAL RESPONSE TO AIRWAY OCCLUSION DURING SLEEP IN NORMAL SUBJECTS [J].

BERRY, RB ;

BONNET, MH ;

LIGHT, RW .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1992, 145 (02) :445-452

[8] Acute effects of paroxetine on genioglossus activity in obstructive sleep apnea [J].

Berry, RB ;

Yamaura, EM ;

Gill, K ;

Reist, C .

SLEEP, 1999, 22 (08) :1087-1092

[9] SLEEP-DISORDERED BREATHING AND NOCTURNAL OXYGEN DESATURATION IN POST-MENOPAUSAL WOMEN [J].

BLOCK, AJ ;

WYNNE, JW ;

BOYSEN, PG .

AMERICAN JOURNAL OF MEDICINE, 1980, 69 (01) :75-79

[10] MENOPAUSE, MEDROXYPROGESTERONE AND BREATHING DURING SLEEP [J].

BLOCK, AJ ;

WYNNE, JW ;

BOYSEN, PG ;

LINDSEY, S ;

MARTIN, C ;

CANTOR, B .

AMERICAN JOURNAL OF MEDICINE, 1981, 70 (03) :506-510

← 1 2 3 4 5 6 7 8 9 10 →