Biomarkers for closed-loop deep brain stimulation in Parkinson disease and beyond

被引：151
作者：
Bouthour, Walid [1 ,2 ]
Megevand, Pierre [1 ,2 ]
Donoghue, John [3 ]
Luscher, Christian [1 ,2 ]
Birbaumer, Niels [3 ,4 ]
Krack, Paul [1 ,2 ,5 ,6 ]
机构：
[1] Geneva Univ Hosp, Div Neurol, Dept Clin Neurosci, Geneva, Switzerland
[2] Univ Geneva, Dept Basic Neurosci, Geneva, Switzerland
[3] Wyss Ctr Bio & Neuroengn, Geneva, Switzerland
[4] Univ Tubingen, Inst Med Psychol & Behav Neurobiol, Tubingen, Germany
[5] Inselspital Bern, Univ Hosp, Dept Neurol, Movement Disorders Ctr, Bern, Switzerland
[6] Univ Bern, Bern, Switzerland
来源：
NATURE REVIEWS NEUROLOGY | 2019年 / 15卷 / 06期
基金：
瑞士国家科学基金会;
关键词：
SUBTHALAMIC NUCLEUS STIMULATION; SUBCALLOSAL CINGULATE GYRUS; MEDIAL FOREBRAIN-BUNDLE; BASAL GANGLIA; MOVEMENT-DISORDERS; BETA OSCILLATIONS; TOURETTE-SYNDROME; BAND ACTIVITY; MOTOR CORTEX; LONG;
D O I：
10.1038/s41582-019-0166-4
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Subthalamic deep brain stimulation (DBS) for Parkinson disease (PD) currently requires laborious open-loop programming, which can mitigate the benefits of this treatment. Experimental closed-loop DBS systems are emerging that can sense the electrophysiological surrogates of PD motor signs and respond with delivery of an automatically adapted stimulation. Such biomarker-based neural interfaces constitute a major advance towards improving the outcomes of patients treated with DBS and enhancing our understanding of the pathophysiological mechanisms underlying PD. In this Perspectives article, we argue that closed-loop DBS, in addition to offering advantages in patients with PD, might extend the current indications for DBS to include selected psychiatric disorders in which the symptoms are similarly driven by pathological brain circuit activity. The success of closed-loop DBS in such settings will depend on the identification of symptom-specific biomarkers, which ideally should reflect causal mechanisms of the underlying pathology.
引用
收藏
页码：343 / 352
页数：10
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