Extracellular Acidification Acts as a Key Modulator of Neutrophil Apoptosis and Functions

被引：31

作者：

Cao, Shannan ^{[1
,2
]}

Liu, Peng ^{[1
,2
]}

Zhu, Haiyan ^{[1
,2
]}

Gong, Haiyan ^{[1
,2
]}

Yao, Jianfeng ^{[3
,4
]}

Sun, Yawei ^{[1
,2
]}

Geng, Guangfeng ^{[1
,2
]}

Wang, Tong ^{[1
,2
]}

Feng, Sizhou ^{[3
,4
]}

Han, Mingzhe ^{[3
,4
]}

Zhou, Jiaxi ^{[1
,2
]}

Xu, Yuanfu ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Hematol & Blood Dis Hosp, State Key Lab Expt Hematol, Tianjin, Peoples R China

[2] Peking Union Med Coll, Tianjin, Peoples R China

[3] Peking Union Med Coll, Inst Hematol & Blood Dis Hosp, Hematopoiet Stem Cell Transplantat Ctr, Tianjin, Peoples R China

[4] Chinese Acad Med Sci, Tianjin, Peoples R China

来源：

PLOS ONE | 2015年 / 10卷 / 09期

关键词：

PROGRAMMED CELL-DEATH; NADPH OXIDASE; PERITONEAL-FLUID; RESPIRATORY BURST; INNATE IMMUNITY; PH-DECREASE; ACIDOSIS; SUPEROXIDE; MACROPHAGES; ACTIVATION;

D O I：

10.1371/journal.pone.0137221

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In human pathological conditions, the acidification of local environment is a frequent feature, such as tumor and inflammation. As the pH of microenvironment alters, the functions of immune cells are about to change. It makes the extracellular acidification a key modulator of innate immunity. Here we detected the impact of extracellular acidification on neutrophil apoptosis and functions, including cell death, respiratory burst, migration and phagocytosis. As a result, we found that under the acid environment, neutrophil apoptosis delayed, respiratory burst inhibited, polarization augmented, chemotaxis differed, endocytosis enhanced and bacteria killing suppressed. These findings suggested that extracellular acidification acts as a key regulator of neutrophil apoptosis and functions.

引用

页数：15

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