Recent advances in Clostridium difficile-associated disease

被引：77

作者：

Monaghan, T. ^{[1
,2
,3
]}

Boswell, T. ^{[2
,4
]}

Mahida, Y. R. ^{[1
,2
,3
]}

机构：

[1] Univ Nottingham, Inst Infect Immun & Inflammat, Nottingham NG7 2UH, England

[2] Nottingham Univ Hosp NHS Trust, Nottingham NG7 2UH, England

[3] Univ Nottingham, Div Gastroenterol, Nottingham NG7 2UH, England

[4] Univ Nottingham, Dept Clin Microbiol, Nottingham NG7 2UH, England

来源：

POSTGRADUATE MEDICAL JOURNAL | 2009年 / 85卷 / 1001期

关键词：

IN-VITRO ACTIVITY; ANTIBIOTIC-ASSOCIATED DIARRHEA; TOXIN-BINDING POLYMER; INTRAVENOUS IMMUNOGLOBULIN; DOUBLE-BLIND; RISK-FACTORS; PSEUDOMEMBRANOUS COLITIS; REDUCED SUSCEPTIBILITY; ENTERIC INFECTION; CONTROLLED-TRIAL;

D O I：

10.1136/gut.2007.128157

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The main purpose of this article is to review recent developments in the management of acute and recurrent Clostridium difficile-associated disease, with consideration of existing and new antibiotic and non-antibiotic agents for treatment. Details of the current developmental stage of new agents are provided and the role of surgery in the management of severe disease is discussed. Infection control measures considered comprise prudent use of antimicrobials, prevention of cross-infection and surveillance. Other topics that are covered include the recent emergence of an epidemic hypervirulent strain, pathogenesis, clinical presentation and approaches to rapid diagnosis and assessment of the colonic disease.

引用

页码：152 / 162

页数：11

共 143 条

[11] The new Clostridium difficile -: What does it mean? [J].