NANODIAMOND LOADED FISH GELATIN ENZYMATICALLY CROSSLINKED HYDROGELS

被引：0

作者：

Olaret, Elena ^{[1
]}

Steinmueller-nethl, Doris ^{[2
]}

Iovu, Horia ^{[1
]}

Stancu, Izabela-Cristina ^{[1
,3
]}

机构：

[1] Univ Politehn Bucuresti, Fac Appl Chem & Mat Sci, Dept Bioresources & Polymer Sci, Adv Polymer Mat Grp, Bucharest, Romania

[2] DiaCoating GmbH, A-6112 Wattens, Austria

[3] Univ Politehn Bucuresti, Fac Med Engn, Bucharest, Romania

来源：

UNIVERSITY POLITEHNICA OF BUCHAREST SCIENTIFIC BULLETIN SERIES B-CHEMISTRY AND MATERIALS SCIENCE | 2022年 / 84卷 / 03期

关键词：

fish gelatin; transglutaminase; enzymatic crosslinking; mechanical properties; diamond nanoparticles; MICROBIAL TRANSGLUTAMINASE; TISSUE TRANSGLUTAMINASE; MECHANICAL-PROPERTIES; BRAIN-TISSUE; SKIN;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This study describes a green route for in-situ synthesis of gelatin-based hydrogels for biomedical applications. Scaffolds based on high protein content were obtained using 50% wt/vol and 70% (wt/vol) fish gelatin, as such or loaded with 1% wt/vol diamond nanoparticles. Transglutaminase was used as crosslinking agent and its network-forming efficiency was evaluated through gel fraction determination. The effects of both protein and nanoparticles were explored through swelling behavior and mechanical properties. Compressive modulus was found to be range of 50-70 kPa while the storage modulus at surface in range of 1-9 kPa.

引用

页码：27 / 40

页数：14

共 41 条

[1] Characteristics of gelatin from the skin of unicorn leatherjacket (Aluterus monoceros) as influenced by acid pretreatment and extraction time [J].

Ahmad, Mehraj ;

Benjakul, Soottawat .

FOOD HYDROCOLLOIDS, 2011, 25 (03) :381-388

[2] Effect of cooling-heating rate on sol-gel transformation of fish gelatin-gum arabic complex coacervate phase [J].

Anvari, Mohammad ;

Chung, Donghwa .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2016, 91 :450-456

[3] Commercial hydrogels for biomedical applications [J].

Aswathy, S. H. ;

Narendrakumar, U. ;

Manjubala, I. .

HELIYON, 2020, 6 (04)

[4] Dynamic indentation on human skin in vivo: ageing effects [J].

Boyer, G. ;

Laquieze, L. ;

Le Bot, A. ;

Laquieze, S. ;

Zahouani, H. .

SKIN RESEARCH AND TECHNOLOGY, 2009, 15 (01) :55-67

[5] Mechanical properties of gray and white matter brain tissue by indentation [J].

Budday, Silvia ;

Nay, Richard ;

de Rooij, Rijk ;

Steinmann, Paul ;

Wyrobek, Thomas ;

Ovaert, Timothy C. ;

Kuhl, Ellen .

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, 2015, 46 :318-330

[6] Physico-chemical, structural and techno-functional properties of gelatin from saithe (Pollachius virens) skin [J].

Casanova, Federico ;

Mohammadifar, Mohammad Amin ;

Jahromi, Mastaneh ;

Petersen, Heidi Olander ;

Sloth, Jens J. ;

Eybye, Karin Loft ;

Kobbelgaard, Sara ;

Jakobsen, Greta ;

Jessen, Flemming .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 156 :918-927

[7] The function of tissue transglutaminase in celiac disease [J].

Di Sabatino, Antonio ;

Vanoli, Alessandro ;

Giuffrida, Paolo ;

Luinetti, Ombretta ;

Solcia, Enrico ;

Corazza, Gino Roberto .

AUTOIMMUNITY REVIEWS, 2012, 11 (10) :746-753

[8] In situ forming injectable hydrogels for drug delivery and wound repair [J].

Dimatteo, Robert ;

Darling, Nicole J. ;

Segura, Tatiana .

ADVANCED DRUG DELIVERY REVIEWS, 2018, 127 :167-184

[9] Transglutaminase 2: an enigmatic enzyme with diverse functions [J].

Fesus, L ;

Piacentini, M .

TRENDS IN BIOCHEMICAL SCIENCES, 2002, 27 (10) :534-539

[10] Assessment of cell viability in a three-dimensional enzymatically cross-linked collagen scaffold [J].

Garcia, Y. ;

Collighan, R. ;

Griffin, M. ;

Pandit, A. .

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2007, 18 (10) :1991-2001

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