Combinatorial expression patterns of heparan sulfate sulfotransferases in zebrafish:: I.: The 3-O-sulfotransferase family

被引:36
作者
Cadwallader, Adam B. [1 ]
Yost, H. Joseph [1 ]
机构
[1] Univ Utah, Ctr Children, Huntsman Canc Inst, Dept Oncol Sci, Salt Lake City, UT 84112 USA
关键词
zebrafish; heparan sulfate; 3-O-sulfotransferase; proteoglycan; 3-OST;
D O I
10.1002/dvdy.20991
中图分类号
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号
100101 ;
摘要
Heparan sulfate (HS) is an unbranched chain of repetitive disaccharides, which specifically binds ligands when attached to the cell surface or secreted extracellularly. HS chains contain sulfated domains termed the HS fine structure, which gives HS specific binding affinities for extracellular ligands. HS 3-O-sulfotransferases (3-OST) catalyze the transfer of sulfate groups to the 3-O position of glucosamine residues of HS, a rare, but essential HS chain modification required for HS fine structure. We report here the first characterization and developmental expression analysis of the 3-OST gene family in a vertebrate. There are eight 3-OST genes in zebrafish: seven genes with homology to known 3-OST genes in mouse and human, as well as a novel, 3-OST-7. A phylogenetic comparison of human, mouse, and zebrafish indicates the 3-OST family can be subdivided into two distinct subgroups. We examined the mRNA expression patterns in several tissues/organs throughout early zebrafish development, including early cleavage stages, somites, brain, internal body organ primordial, and pectoral fin development. The 3-OST gene family has both specifically expressed and ubiquitously expressed genes, suggesting in vivo functional differences exist between members of this family.
引用
收藏
页码:3423 / 3431
页数:9
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