Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction

被引：75

作者：

de Carvalho, Leonardo P. ^{[1
,2
,3
,4
]}

Tan, Sock Hwee ^{[2
,3
]}

Ow, Ghim-Siong ^{[5
]}

Tang, Zhiqun ^{[5
,6
]}

Ching, Jianhong ^{[7
]}

Kovalik, Jean-Paul ^{[7
]}

Poh, Sock Cheng ^{[2
]}

Chin, Chee-Tang ^{[7
,8
]}

Richards, A. Mark ^{[2
,9
]}

Martinez, Eliana C. ^{[10
]}

Troughton, Richard W. ^{[9
]}

Fong, Alan Yean-Yip ^{[11
,12
]}

Yan, Bryan P. ^{[13
]}

Seneviratna, Aruni ^{[2
]}

Sorokin, Vitaly ^{[2
,3
]}

Summers, Scott A. ^{[14
]}

Kuznetsov, Vladimir A. ^{[5
,15
]}

Chan, Mark Y. ^{[2
,3
]}

机构：

[1] Fed Univ Sao Paulo State, Sao Paulo, Brazil

[2] Natl Univ Heart Ctr, Singapore, Singapore

[3] Natl Univ Singapore, Yong Loo Lin Sch Med, Cardiovasc Res Inst, Singapore, Singapore

[4] Albert Einstein Hosp, Sao Paulo, Brazil

[5] ASTAR, Bioinformat Inst, Singapore, Singapore

[6] ASTAR, Inst Mol & Cell Biol, Singapore, Singapore

[7] Duke Natl Univ Singapore Grad Med Sch, Program Cardiovasc & Metab Disorders, Singapore, Singapore

[8] Natl Heart Ctr Singapore, Singapore, Singapore

[9] Univ Otago Christchurch, Christchurch Hosp, Christchurch Heart Inst, Christchurch, New Zealand

[10] Univ Miami, Miller Sch Med, Miami, FL 33136 USA

[11] Sarawak Gen Hosp, Clin Res Ctr, Kuching, Malaysia

[12] Sarawak Gen Hosp, Dept Cardiol, Kuching, Malaysia

[13] Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Peoples R China

[14] Univ Utah, Salt Lake City, UT USA

[15] Nanyang Technol Univ, Nanyang Inst Technol Hlth & Med, Singapore, Singapore

来源：

JACC-BASIC TO TRANSLATIONAL SCIENCE | 2018年 / 3卷 / 02期

基金：

英国医学研究理事会;

关键词：

acute coronary syndrome; ceramides; dihydroceramides; major adverse cardiovascular and cerebrovascular events; prognosis; risk prediction; BREAST-CANCER; SPHINGOLIPIDS; METABOLISM; ACCUMULATION; APOPTOSIS; PATHWAY; DISEASE; MARKER; PLAQUE; HEART;

D O I：

10.1016/j.jacbts.2017.12.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We identified a plasma signature of 11 C14 to C26 ceramides and 1 C16 dihydroceramide predictive of major adverse cardiovascular events in patients with acute myocardial infarction (AMI). Among patients undergoing coronary artery bypass surgery, those with recent AMI, compared with those without recent AMI, showed a significant increase in 5 of the signature's 12 ceramides in plasma but not simultaneously-biopsied aortic tissue. In contrast, a rat AMI model, compared with sham control, showed a significant increase in myocardial concentrations of all 12 ceramides and up-regulation of 3 ceramide-producing enzymes, suggesting ischemic myocardium as a possible source of this ceramide signature. (C) 2018 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.

引用

页码：164 / 175

页数：12

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