Is ALS caused by an altered oxidative activity of mutant superoxide dismutase?

被引：28
作者：
Bush, AI
机构：
[1] Massachusetts Gen Hosp, Lab Oxidat Biol, Genet & Aging Res Unit, Charlestown, MA 02129 USA
[2] Univ Melbourne, Dept Pathol, Parkville, Vic 3052, Australia
[3] Univ Melbourne, Mental Hlth Res Inst, Oxidat Disorders Lab, Parkville, Vic 3052, Australia
来源：
NATURE NEUROSCIENCE | 2002年 / 5卷 / 10期
关键词：
D O I：
10.1038/nn1002-919a
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
引用
收藏
页码：919 / 919
页数：1
相关论文
共 12 条
  • [1] Increased reactive oxygen species in familial amyotrophic lateral sclerosis with mutations in SOD1
    Ahmed, MS
    Hung, WY
    Zu, JS
    Hockberger, P
    Siddique, T
    [J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 2000, 176 (02) : 88 - 94
  • [2] The copper chaperone for superoxide dismutase
    Culotta, VC
    Klomp, LWJ
    Strain, J
    Casareno, RLB
    Krems, B
    Gitlin, JD
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (38) : 23469 - 23472
  • [3] Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase
    Estévez, AG
    Crow, JP
    Sampson, JB
    Reiter, C
    Zhuang, YX
    Richardson, GJ
    Tarpey, MM
    Barbeito, L
    Beckman, JS
    [J]. SCIENCE, 1999, 286 (5449) : 2498 - 2500
  • [4] Loss of in vitro metal ion binding specificity in mutant copper-zinc superoxide dismutases associated with familial amyotrophic lateral sclerosis
    Goto, JJ
    Zhu, HN
    Sanchez, RJ
    Nersissian, A
    Gralla, EB
    Valentine, JS
    Cabelli, DE
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (02) : 1007 - 1014
  • [5] The copper chelator d-penicillamine delays onset of disease and extends survival in a transgenic mouse model of familial amyotrophic lateral sclerosis
    Hottinger, AF
    Fine, EG
    Gurney, ME
    Zurn, AD
    Aebischer, P
    [J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 1997, 9 (07) : 1548 - 1551
  • [6] Copper(2+) binding to the surface residue cysteine 111 of His46Arg human copper-zinc superoxide dismutase, a familial amyotrophic lateral sclerosis mutant
    Liu, HB
    Zhu, HN
    Eggers, DK
    Nersissian, AM
    Faull, KF
    Goto, JJ
    Ai, JY
    Sanders-Loehr, J
    Gralla, EB
    Valentine, JS
    [J]. BIOCHEMISTRY, 2000, 39 (28) : 8125 - 8132
  • [7] Benefit of a combined treatment with trientine and ascorbate in familial amyotrophic lateral sclerosis model mice
    Nagano, S
    Ogawa, Y
    Yanagihara, T
    Sakoda, S
    [J]. NEUROSCIENCE LETTERS, 1999, 265 (03) : 159 - 162
  • [8] Reduction of metallothioneins promotes the disease expression of familial amyotrophic lateral sclerosis mice in a dose-dependent manner
    Nagano, S
    Satoh, M
    Sumi, H
    Fujimura, H
    Tohyama, C
    Yanagihara, T
    Sakoda, S
    [J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 2001, 13 (07) : 1363 - 1370
  • [9] A proposed mechanism of ALS fails the test in vivo
    Orr, HT
    [J]. NATURE NEUROSCIENCE, 2002, 5 (04) : 287 - 288
  • [10] Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading
    Subramaniam, JR
    Lyons, WE
    Liu, J
    Bartnikas, TB
    Rothstein, J
    Price, DL
    Cleveland, DW
    Gitlin, JD
    Wong, PC
    [J]. NATURE NEUROSCIENCE, 2002, 5 (04) : 301 - 307
12