Multidrug efflux pumps: structure, function and regulation (vol 16, pg 523, 2018)

被引：6

作者：

Du, Dijun

Wang-Kan, Xuan

Neuberger, Arthur

van Veen, Hendrik W.

Pos, Klaas M.

Piddock, Laura J. V.

Luisi, Ben F.

机构：

[1] Department of Biochemistry, University of Cambridge, Cambridge

[2] Institute of Microbiology and Infection, University of Birmingham, Birmingham

[3] Department of Pharmacology, University of Cambridge, Cambridge

[4] Institute of Biochemistry, Goethe Universität Frankfurt, Frankfurt

来源：

NATURE REVIEWS MICROBIOLOGY | 2018年 / 16卷 / 09期

基金：

欧洲研究理事会; 英国医学研究理事会; 英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1038/s41579-018-0060-x

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Infections arising from multidrug-resistant pathogenic bacteria are spreading rapidly throughout the world and threaten to become untreatable. The origins of resistance are numerous and complex, but one underlying factor is the capacity of bacteria to rapidly export drugs through the intrinsic activity of efflux pumps. In this Review, we describe recent advances that have increased our understanding of the structures and molecular mechanisms of multidrug efflux pumps in bacteria. Clinical and laboratory data indicate that efflux pumps function not only in the drug extrusion process but also in virulence and the adaptive responses that contribute to antimicrobial resistance during infection. The emerging picture of the structure, function and regulation of efflux pumps suggests opportunities for countering their activities.

引用

页码：577 / 577

页数：1