Cobalt-catalyzed tandem one-pot synthesis of polysubstituted imidazo[1,5-a]pyridines and imidazo[1,5-a]isoquinolines

被引：6

作者：

Meena, Neha ^{[1
]}

Dhiman, Shiv ^{[1
]}

Rangan, Krishnan ^{[2
]}

Kumar, Anil ^{[1
]}

机构：

[1] Birla Inst Technol & Sci, Dept Chem, Pilani 333031, Rajasthan, India

[2] Birla Inst Technol & Sci Pilani, Dept Chem, Hyderabad 500078, Telangana, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2022年 / 20卷 / 20期

关键词：

H BOND FUNCTIONALIZATION; KNOEVENAGEL CONDENSATION; OXIDATIVE AMINATION; DUAL EMISSION; TRANSANNULATION; PYRIDOTRIAZOLES; DERIVATIVES; IMIDAZOLES; ACTIVATION; ARYLATION;

D O I：

10.1039/d2ob00526c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient cobalt-catalyzed tandem one-pot method has been developed for the synthesis of polysubstituted imidazo[1,5-a]-N-heteroaromatics. The method involves Knoevenagel condensation followed by cobalt-catalyzed direct alkenylation to give the desired polysubstituted imidazo[1,5-a]pyridines and imidazo[1,5-a]isoquinolines in a one-pot manner. This method exhibits a broad substrate scope, provides moderate to good (39-74%) yields and is amenable to scale-up to the gram scale.

引用

页码：4215 / 4223

页数：9

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