Sea level rise (SLR) and tropical cyclone (TC) climatology change could impact future flood hazards in Jamaica Bay-an urbanized back-barrier bay in New York-yet their compound impacts are not well understood. This study estimates the compound effects of SLR and TC climatology change on flood hazards in Jamaica Bay from a historical period in the late twentieth century (1980-2000) to future periods in the mid- and late-twenty-first century (2030-2050 and 2080-2100, under RCP8.5 greenhouse gas concentration scenario). Flood return periods are estimated based on probabilistic projections of SLR and peak storm tides simulated by a hydrodynamic model for large numbers of synthetic TCs. We find a substantial increase in the future flood hazards, e.g., the historical 100-year flood level would become a 9- and 1-year flood level in the mid- and late-twenty-first century and the 500-year flood level would become a 143- and 4-year flood level. These increases are mainly induced by SLR. However, TC climatology change would considerably contribute to the future increase in low-probability, high-consequence flood levels (with a return period greater than 100 year), likely due to an increase in the probability of occurrence of slow-moving but intense TCs by the end of twenty-first century. We further conduct high-resolution coastal flood simulations for a series of SLR and TC scenarios. Due to the SLR projected with a 5% exceedance probability, 125- and 1300-year flood events in the late-twentieth century would become 74- and 515-year flood events, respectively, in the late-twenty-first century, and the spatial extent of flooding over coastal floodplains of Jamaica Bay would increase by nearly 10 and 4 times, respectively. In addition, SLR leads to larger surface waves induced by TCs in the bay, suggesting a potential increase in hazards associated with wave runup, erosion, and damage to coastal infrastructure.