Vic-Tricarbonyl Compounds: Synthesis of (±)-9-epi-Wailupemycin A (vol 46, pg 381, 2014)

被引：16

作者：

Seitz, Tobias

Harms, Klaus

Koert, Ulrich

机构：

[1] Fachbereich Chemie, Philipps-Universität Marburg, 35043 Marburg, Hans-Meerwein-Straße

来源：

SYNTHESIS-STUTTGART | 2014年 / 46卷 / 03期

关键词：

α-pyrone; enamine; natural products; stereoselective synthesis; vicinal tricarbonyl compound;

D O I：

10.1055/s-0033-1340313

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthesis of the 9-epimer of the marine natural product wailupemycin A is reported. The key reaction sequence consists of a diastereoselective enamine addition to a tricarbonyl monohydrate, the formation of an enol silyl acetal, and finally the stereocontrolled addition of the a-pyrone substructure.

引用

页码：E1 / E1

页数：1