The defense response of Caenorhabditis elegans to Cutibacterium acnes SK137 via the TIR-1-p38 MAPK signaling pathway

被引：2

作者：

Tsuru, Ayano ^{[1
]}

Hamazaki, Yumi ^{[1
]}

Tomida, Shuta ^{[2
]}

Ali, Mohammad Shaokat ^{[1
,3
]}

Kage-Nakadai, Eriko ^{[1
]}

机构：

[1] Osaka City Univ, Grad Sch Human Life Sci, Osaka 5588585, Japan

[2] Okayama Univ Hosp, Ctr Comprehens Genom Med, Okayama 7008558, Japan

[3] Chattogram Vet & Anim Sci Univ, Fac Food Sci & Technol, Chattogram 4225, Bangladesh

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2022年 / 86卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Caenorhabditis elegans; Cutibacterium acnes; p38; MAPK; tir-1; antimicrobial molecule; PROPIONIBACTERIUM-ACNES; SKIN; GENETICS;

D O I：

10.1093/bbb/zbab218

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cutibacterium acnes plays roles in both acne disease and healthy skin ecosystem. We observed that mutations in the tir-1/SARM1 and p38 MAPK cascade genes significantly shortened Caenorhabditis elegans lifespan upon C. acnes SK137 infection. Antimicrobial molecules were induced by SK137 in a TIR-1-dependent manner. These results suggest that defense responses against SK137 involve the TIR-1-p38 MAPK pathway in C. elegans.

引用

页码：374 / 379

页数：6

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