Membrane Lipids Tune Synaptic Transmission by Direct Modulation of Presynaptic Potassium Channels

被引：69

作者：

Carta, Mario ^{[1
]}

Lanore, Frederic ^{[1
]}

Rebola, Nelson ^{[1
]}

Szabo, Zsolt ^{[1
]}

Da Silva, Silvia Viana ^{[1
]}

Lourenco, Joana ^{[1
]}

Verraes, Agathe ^{[3
,4
]}

Nadler, Andre ^{[2
]}

Schultz, Carsten ^{[2
]}

Blanchet, Christophe ^{[1
]}

Mulle, Christophe ^{[1
]}

机构：

[1] Univ Bordeaux, Interdisciplinary Inst Neurosci, CNRS UMR 5297, F-33000 Bordeaux, France

[2] EMBL Heidelberg, D-69117 Heidelberg, Germany

[3] Univ Paris Diderot, Inst Jacques Monod, Sorbonne Paris Cite, CNRS,UMR 7592, F-75013 Paris, France

[4] Univ Paris Diderot, INSERM ERL U950, Sorbonne Paris Cite, F-75013 Paris, France

来源：

NEURON | 2014年 / 81卷 / 04期

关键词：

LONG-TERM POTENTIATION; CA1 PYRAMIDAL NEURONS; MOSSY FIBER BOUTONS; ARACHIDONIC-ACID; CANNABINOID RECEPTOR; K+ CHANNELS; NEUROTRANSMITTER RELEASE; RETROGRADE SUPPRESSION; ADENYLYL-CYCLASE; CA2+ CHANNELS;

D O I：

10.1016/j.neuron.2013.12.028

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Voltage-gated potassium (Kv) channels are involved in action potential (AP) repolarization in excitable cells. Exogenous application of membrane-derived lipids, such as arachidonic acid (AA), regulates the gating of Kv channels. Whether membrane-derived lipids released under physiological conditions have an impact on neuronal coding through this mechanism is unknown. We show that AA released in an activity-dependent manner from postsynaptic hippocampal CA3 pyramidal cells acts as retrograde messenger, inducing a robust facilitation of mossy fiber (Mf) synaptic transmission over several minutes. AA acts by broadening presynaptic APs through the direct modulation of Kv channels. This form of short-term plasticity can be triggered when postsynaptic cell fires with physiologically relevant patterns and sets the threshold for the induction of the presynaptic form of long-term potentiation (LTP) at hippocampal Mf synapses. Hence, direct modulation of presynaptic Kv channels by activity-dependent release of lipids serves as a physiological mechanism for tuning synaptic transmission.

引用

页码：787 / 799

页数：13

共 55 条

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