Effect of evodiamine on cell death pathways in human gastric cancer cells

被引：0
作者：
Zhang, Hanni [2 ]
Liu, Liping [1 ]
Li, Pingxiang [1 ]
Guo, Yunliang [1 ]
Ge, Keli [1 ]
机构：
[1] Qingdao Univ, Inst Integrated Med, Med Coll, Qingdao, Shandong, Peoples R China
[2] Wuhan Puren Hosp, Dept Acupuncture, Wuhan, Hubei, Peoples R China
来源：
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2022年 / 35卷 / 06期
关键词：
Evodiamine; human gastric cancer; ROS; cytotoxicity; apoptosis; necroptosis; CYCLE ARREST; APOPTOSIS; RECOMMENDATIONS; INHIBITION; MECHANISMS; PI3K/AKT; KINASE;
D O I：
10.36721/PJPS.2022.35.6.REG.1523-1529.1KeliGeet
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Evodiamine (EVO) exerts anti-cancer effect in a majority of cancer cells. BGC-823 and SGC-7901 cells were used to study EVO-induced cytotoxicity in human gastric cancer cell. Our results demonstrated that EVO exposure elicited cell vialibility decrease and G2/M arrest caused by induction of cdc2/cyclin B1 complex activation. EVO also induced caspase-dependent apoptosis and necroptosis caused by induction of actication of RIP, RIP3 and MLKL. Moreover, increase of reactive oxygen species (ROS) levels and cytotoxicity induced by EVO were significantly attenuated by co-treatment with a ROS scavenger, EUK134. In conclusion, EVO induced ROS-dependent cytotoxicity, which may involve apoptosis and necroptosis, in human gastric cancer cells.
引用
收藏
页码：1523 / 1529
页数：7
相关论文
共 40 条
  • [1] Role of mitochondria and mitochondria-targeted agents in non-alcoholic fatty liver disease
    Ajith, Thekkuttuparambil Ananthanarayanan
    [J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2018, 45 (05) : 413 - 421
  • [2] [Anonymous], 2022, PAK J PHARM SCI, V35, P1523
  • [3] Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity
    Booher, RN
    Holman, PS
    Fattaey, A
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (35) : 22300 - 22306
  • [4] Oxidative Stress Resulting From Helicobacter pylori Infection Contributes to Gastric Carcinogenesis
    Butcher, Lindsay D.
    den Hartog, Gerco
    Ernst, Peter B.
    Crowe, Sheila E.
    [J]. CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2017, 3 (03): : 316 - 322
  • [5] Identification of evodiamine as a suppressor of prostate cancer progression by reducing AR transcriptional activity via targeting Src
    Cheng, Pei
    Zhang, Xiaofan
    Wang, Xiaofu
    Liu, Changwei
    Zhao, Xinghua
    Fan, Junfang
    Xu, Changbao
    [J]. ENDOCRINE, 2022, 75 (02) : 635 - 645
  • [6] Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
    Czabotar, Peter E.
    Lessene, Guillaume
    Strasser, Andreas
    Adams, Jerry M.
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2014, 15 (01) : 49 - 63
  • [7] Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies
    Delbridge, Alex R. D.
    Grabow, Stephanie
    Strasser, Andreas
    Vaux, David L.
    [J]. NATURE REVIEWS CANCER, 2016, 16 (02) : 99 - 109
  • [8] Advanced gastric cancer: Current treatment landscape and future perspectives
    Digklia, Antonia
    Wagner, Anna Dorothea
    [J]. WORLD JOURNAL OF GASTROENTEROLOGY, 2016, 22 (08) : 2403 - 2414
  • [9] Berberine and Evodiamine Act Synergistically Against Human Breast Cancer MCF-7 Cells by Inducing Cell Cycle Arrest and Apoptosis
    Du, Jia
    Sun, Yang
    Lu, Yi-Yu
    Lau, Eric
    Zhao, Ming
    Zhou, Qian-Mei
    Su, Shi-Bing
    [J]. ANTICANCER RESEARCH, 2017, 37 (11) : 6141 - 6151
  • [10] Staurosporine Induces Necroptotic Cell Death under Caspase-Compromised Conditions in U937 Cells
    Dunai, Zsuzsanna A.
    Imre, Gergely
    Barna, Gabor
    Korcsmaros, Tamas
    Petak, Istvan
    Bauer, Pal I.
    Mihalik, Rudolf
    [J]. PLOS ONE, 2012, 7 (07):
1234