Effect of evodiamine on cell death pathways in human gastric cancer cells

被引：0

作者：

Zhang, Hanni ^{[2
]}

Liu, Liping ^{[1
]}

Li, Pingxiang ^{[1
]}

Guo, Yunliang ^{[1
]}

Ge, Keli ^{[1
]}

机构：

[1] Qingdao Univ, Inst Integrated Med, Med Coll, Qingdao, Shandong, Peoples R China

[2] Wuhan Puren Hosp, Dept Acupuncture, Wuhan, Hubei, Peoples R China

来源：

PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2022年 / 35卷 / 06期

关键词：

Evodiamine; human gastric cancer; ROS; cytotoxicity; apoptosis; necroptosis; CYCLE ARREST; APOPTOSIS; RECOMMENDATIONS; INHIBITION; MECHANISMS; PI3K/AKT; KINASE;

D O I：

10.36721/PJPS.2022.35.6.REG.1523-1529.1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Evodiamine (EVO) exerts anti-cancer effect in a majority of cancer cells. BGC-823 and SGC-7901 cells were used to study EVO-induced cytotoxicity in human gastric cancer cell. Our results demonstrated that EVO exposure elicited cell vialibility decrease and 02/M arrest caused by induction of cdc2/cyclin B1 complex activation. EVO also induced caspase-dependent apoptosis and necroptosis caused by induction of actication of RIP, RIP3 and MLKL. Moreover, increase of reactive oxygen species (ROS) levels and cytotoxicity induced by EVO were significantly attenuated by co-treatment with a ROS scavenger, EUK134. In conclusion, EVO induced ROS-dependent cytotoxicity, which may involve apoptosis and necroptosis, in human gastric cancer cells.

引用

页码：1523 / 1529

页数：7

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