Clinicopathologic Findings in Fatal Neurotoxicity After Adoptive Immunotherapy With CD19-Directed CAR T-Cells

被引:10
作者
Karschnia, Philipp [1 ,2 ]
Struebing, Felix [3 ]
Teske, Nico [1 ,2 ]
Blumenberg, Viktoria [2 ,4 ,5 ,6 ]
Buecklein, Veit L. [2 ,4 ,5 ,6 ]
Schmidt, Christian [2 ,4 ,5 ]
Schoeberl, Florian [7 ]
Dimitriadis, Konstantinos [7 ]
Forbrig, Robert [8 ]
Stemmler, Hans-Joachim [2 ,4 ,5 ]
Tonn, Joerg-Christian [1 ,2 ]
Von Bergwelt-Baildon, Michael [2 ,4 ,5 ]
Subklewe, Marion [2 ,4 ,5 ,6 ]
von Baumgarten, Louisa [1 ,2 ,7 ]
机构
[1] Ludwig Maximilians Univ Munchen, Dept Neurosurg, Div Neurooncol, Sch Med, Munich, Germany
[2] German Canc Consortium DKTK, Partner Site Munich, Munich, Germany
[3] Ludwig Maximilians Univ Munchen, Ctr Neuropathol & Prion Res, Sch Med, Munich, Germany
[4] Ludwig Maximilians Univ Munchen, Sch Med, Dept Med, Hematol & Oncol Div, Munich, Germany
[5] Ludwig Maximilians Univ Munchen, Sch Med, Cellular Immunotherapy Program, Munich, Germany
[6] Ludwig Maximilians Univ Munchen, Lab Translat Canc Immunol, Gene Ctr, Munich, Germany
[7] Ludwig Maximilians Univ Munchen, Dept Neurol, Sch Med, Munich, Germany
[8] Ludwig Maximilians Univ Munchen, Dept Neuroradiol, Sch Med, Munich, Germany
基金
欧盟地平线“2020”;
关键词
CD19;
D O I
10.1097/HS9.0000000000000533
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页数:4
相关论文
共 14 条
[1]   Glial injury in neurotoxicity after pediatric CD19-directed chimeric antigen receptor T cell therapy [J].
Gust, Juliane ;
Finney, Olivia C. ;
Li, Daniel ;
Brakke, Hannah M. ;
Hicks, Roxana M. ;
Futrell, Robert B. ;
Gamble, Danielle N. ;
Rawlings-Rhea, Stephanie D. ;
Khalatbari, Hedieh K. ;
Ishak, Gisele E. ;
Duncan, Virginia E. ;
Hevner, Robert F. ;
Jensen, Michael C. ;
Park, Julie R. ;
Gardner, Rebecca A. .
ANNALS OF NEUROLOGY, 2019, 86 (01) :42-54
[2]   Endothelial Activation and Blood-Brain Barrier Disruption in Neurotoxicity after Adoptive Immunotherapy with CD19 CAR-T Cells [J].
Gust, Juliane ;
Hay, Kevin A. ;
Hanafi, Laila-Aicha ;
Li, Daniel ;
Myerson, David ;
Gonzalez-Cuyar, Luis F. ;
Yeung, Cecilia ;
Liles, W. Conrad ;
Wurfel, Mark ;
Lopez, Jose A. ;
Chen, Junmei ;
Chung, Dominic ;
Harju-Baker, Susanna ;
Tzpolat, Tahsin ;
Fink, Kathleen R. ;
Riddell, Stanley R. ;
Maloney, David G. ;
Turtle, Cameron J. .
CANCER DISCOVERY, 2017, 7 (12) :1404-1419
[3]   CAR T-Cell Associated Neurotoxicity: Mechanisms, Clinicopathologic Correlates, and Future Directions [J].
Hunter, Bradley D. ;
Jacobson, Caron A. .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2019, 111 (07) :646-654
[4]   Clinical presentation, management, and biomarkers of neurotoxicity after adoptive immunotherapy with CAR T cells [J].
Karschnia, Philipp ;
Jordan, Justin T. ;
Forst, Deborah A. ;
Arrillaga-Romany, Isabel C. ;
Batchelor, Tracy T. ;
Baehring, Joachim M. ;
Clement, Nathan F. ;
Castro, L. Nicolas Gonzalez ;
Herlopian, Aline ;
Maus, Marcela, V ;
Schwaiblmair, Michaela H. ;
Soumerai, Jacob D. ;
Takvorian, Ronald W. ;
Hochberg, Ephraim P. ;
Barnes, Jeffrey A. ;
Abramson, Jeremy S. ;
Frigault, Matthew J. ;
Dietrich, Jorg .
BLOOD, 2019, 133 (20) :2212-2221
[5]   ASTCT Consensus Grading for Cytokine Release Syndrome and Neurologic Toxicity Associated with Immune Effector Cells [J].
Lee, Daniel W. ;
Santomasso, Bianca D. ;
Locke, Frederick L. ;
Ghobadi, Armin ;
Turtle, Cameron J. ;
Brudno, Jennifer N. ;
Maus, Marcela, V ;
Park, Jae H. ;
Mead, Elena ;
Pavletic, Steven ;
Go, William Y. ;
Eldjerou, Lamis ;
Gardner, Rebecca A. ;
Frey, Noelle ;
Curran, Kevin J. ;
Peggs, Karl ;
Pasquini, Marcelo ;
DiPersio, John F. ;
van den Brink, Marcel R. M. ;
Komanduri, Krishna, V ;
Grupp, Stephan A. ;
Neelapu, Sattva S. .
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2019, 25 (04) :625-638
[6]   Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia [J].
Maude, S. L. ;
Laetsch, T. W. ;
Buechner, J. ;
Rives, S. ;
Boyer, M. ;
Bittencourt, H. ;
Bader, P. ;
Verneris, M. R. ;
Stefanski, H. E. ;
Myers, G. D. ;
Qayed, M. ;
De Moerloose, B. ;
Hiramatsu, H. ;
Schlis, K. ;
Davis, K. L. ;
Martin, P. L. ;
Nemecek, E. R. ;
Yanik, G. A. ;
Peters, C. ;
Baruchel, A. ;
Boissel, N. ;
Mechinaud, F. ;
Balduzzi, A. ;
Krueger, J. ;
June, C. H. ;
Levine, B. L. ;
Wood, P. ;
Taran, T. ;
Leung, M. ;
Mueller, K. T. ;
Zhang, Y. ;
Sen, K. ;
Lebwohl, D. ;
Pulsipher, M. A. ;
Grupp, S. A. .
NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (05) :439-448
[7]   Double-negative T cells remarkably promote neuroinflammation after ischemic stroke [J].
Meng, Hailan ;
Zhao, Haoran ;
Cao, Xiang ;
Hao, Junwei ;
Zhang, He ;
Liu, Yi ;
Zhu, Min-sheng ;
Fan, Lizhen ;
Weng, Leihua ;
Qian, Lai ;
Wang, Xiaoying ;
Xu, Yun .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (12) :5558-5563
[8]   Long-term in vivo microscopy of CAR T cell dynamics during eradication of CNS lymphoma in mice [J].
Mulazzani, Matthias ;
Fraessle, Simon P. ;
von Muecke-Heim, Iven ;
Langer, Sigrid ;
Zhou, Xiaolan ;
Ishikawa-Ankerhold, Hellen ;
Leube, Justin ;
Zhang, Wenlong ;
Dotsch, Sarah ;
Svec, Mortimer ;
Rudelius, Martina ;
Dreyling, Martin ;
von Bergwelt-Baildon, Michael ;
Straube, Andreas ;
Buchholz, Veit R. ;
Busch, Dirk H. ;
von Baumgarten, Louisa .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (48) :24275-24284
[9]   Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma [J].
Neelapu, S. S. ;
Locke, F. L. ;
Bartlett, N. L. ;
Lekakis, L. J. ;
Miklos, D. B. ;
Jacobson, C. A. ;
Braunschweig, I. ;
Oluwole, O. O. ;
Siddiqi, T. ;
Lin, Y. ;
Timmerman, J. M. ;
Stiff, P. J. ;
Friedberg, J. W. ;
Flinn, I. W. ;
Goy, A. ;
Hill, B. T. ;
Smith, M. R. ;
Deol, A. ;
Farooq, U. ;
McSweeney, P. ;
Munoz, J. ;
Avivi, I. ;
Castro, J. E. ;
Westin, J. R. ;
Chavez, J. C. ;
Ghobadi, A. ;
Komanduri, K. V. ;
Levy, R. ;
Jacobsen, E. D. ;
Witzig, T. E. ;
Reagan, P. ;
Bot, A. ;
Rossi, J. ;
Navale, L. ;
Jiang, Y. ;
Aycock, J. ;
Elias, M. ;
Chang, D. ;
Wiezorek, J. ;
Go, W. Y. .
NEW ENGLAND JOURNAL OF MEDICINE, 2017, 377 (26) :2531-2544
[10]   Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells [J].
Norelli, Margherita ;
Camisa, Barbara ;
Barbiera, Giulia ;
Falcone, Laura ;
Purevdorj, Ayurzana ;
Genua, Marco ;
Sanvito, Francesca ;
Ponzoni, Maurilio ;
Doglioni, Claudio ;
Cristofori, Patrizia ;
Traversari, Catia ;
Bordignon, Claudio ;
Ciceri, Fabio ;
Ostuni, Renato ;
Bonini, Chiara ;
Casucci, Monica ;
Bondanza, Attilio .
NATURE MEDICINE, 2018, 24 (06) :739-+