Iridium-catalyzed enantioselective olefinic C(sp2)-H allylic alkylation (vol 12, pg 3070, 2021)

被引：1

作者：

Sarkar, Rahul ^{[1
]}

Mukherjee, Santanu ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India

来源：

CHEMICAL SCIENCE | 2021年 / 12卷 / 08期

关键词：

D O I：

10.1039/d1sc90022f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first iridium-catalyzed enantioselective olefinic C(sp2)-H allylic alkylation is developed in cooperation with Lewis base catalysis. This reaction, catalyzed by cinchonidine and anin situgenerated cyclometalated Ir(i)/phosphoramidite complex, makes use of the latent enolate character of an α,β-unsaturated carbonyl compound, namely coumalate ester, to introduce an allyl group at its α-position in a branched-selective manner in moderate to good yield with good to excellent enantioselectivities (up to 98 : 2 er). © The Royal Society of Chemistry 2021.

引用

页码：3076 / 3076

页数：1