Association between expanded criteria for living kidney donors and renal biopsy findings (Jan, 10.1007/s40620-021-01228-2, 2022)

被引：1

作者：

Goto, Shunsuke ^{[1
,2
]}

Oguchi, Hideyo ^{[3
]}

Sakai, Ken ^{[3
]}

Mikami, Tetsuo ^{[4
]}

Ichikawa, Daisuke ^{[5
]}

Yazawa, Masahiko ^{[5
]}

Koike, Junki ^{[6
]}

Furuichi, Kengo ^{[7
]}

Kawabata, Masahiko ^{[8
]}

Yokoyama, Hitoshi ^{[7
]}

Sofue, Tadashi ^{[9
]}

Ibuki, Emi ^{[10
]}

Nishi, Shinichi ^{[1
,2
]}

机构：

[1] Kobe Univ, Grad Sch Med, Div Nephrol, Chuo Ku, 7-5-2 Kusunoki Cho, Kobe, Hyogo 6500017, Japan

[2] Kobe Univ, Grad Sch Med, Kidney Ctr, Chuo Ku, 7-5-2 Kusunoki Cho, Kobe, Hyogo 6500017, Japan

[3] Toho Univ, Dept Nephrol, Fac Med, Tokyo, Japan

[4] Toho Univ, Dept Pathol, Fac Med, Tokyo, Japan

[5] St Marianna Univ, Sch Med, Dept Internal Med, Div Nephrol & Hypertens, Kawasaki, Kanagawa, Japan

[6] St Marianna Univ, Sch Med, Dept Diagnost Pathol, Kawasaki, Kanagawa, Japan

[7] Kanazawa Med Univ, Dept Nephrol, Sch Med, Uchinada, Ishikawa, Japan

[8] Toyama Prefectural Cent Hosp, Dept Internal Med, Toyama, Japan

[9] Kagawa Univ, Div Nephrol & Dialysis, Dept Cardiorenal & Cerebrovasc Med, Takamatsu, Kagawa, Japan

[10] Kagawa Univ, Dept Diagnost Pathol, Takamatsu, Kagawa, Japan

来源：

JOURNAL OF NEPHROLOGY | 2022年 / 35卷 / 07期

关键词：

Arteriolar hyalinosis; Global glomerulosclerosis; Intimal thickening; Kidney transplantation; Living kidney donor; Tubular atrophy;

D O I：

10.1007/s40620-022-01285-1

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Background: There are certain criteria for selecting living kidney donors. However, the association between clinical characteristics of these criteria and kidney biopsy findings in living kidney donors have not yet been elucidated. Thus, we investigated the association between kidney biopsy findings and clinical characteristics defined in the Japanese guidelines for living kidney donors. Methods: A retrospective multicentre study was conducted on donors and their recipients who underwent kidney transplantation between July 2014 and June 2017. Multiple linear regression analysis and multiple logistic regression analysis were performed to investigate the association between biopsy findings and clinical characteristics. Results: A total of 240 donors and 240 recipients were included. Age was significantly correlated with global glomerulosclerosis and intimal thickening in multiple linear regression analysis and multiple logistic regression analysis, whereas diabetes was correlated with tubular atrophy in multiple linear regression analysis after multiple imputation and multiple logistic regression analysis. Conclusions: Amongst the clinical factors investigated in our study, age was positively correlated and diabetes was possibly correlated with kidney tissue injury in living kidney donors. Age and diabetes may be more important for selecting suitable living kidney donors than other clinical factors. Graphical Abstract: [Figure not available: see fulltext.] © 2021, The Author(s) under exclusive licence to Italian Society of Nephrology.

引用

页码：1947 / 1947

页数：1