Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence

被引：290

作者：

Sniekers, Suzanne ^{[1
]}

Stringer, Sven ^{[1
]}

Watanabe, Kyoko ^{[1
]}

Jansen, Philip R. ^{[1
,2
]}

Coleman, Jonathan R. I. ^{[3
,4
]}

Krapohl, Eva ^{[3
]}

Taskesen, Erdogan ^{[1
,5
]}

Hammerschlag, Anke R. ^{[1
]}

Okbay, Aysu ^{[1
,6
]}

Zabaneh, Delilah ^{[3
]}

Amin, Najaf ^{[7
]}

Breen, Gerome ^{[3
,4
]}

Cesarini, David ^{[8
]}

Chabris, Christopher F. ^{[9
,21
]}

Iacono, William G. ^{[10
]}

Ikram, M. Arfan ^{[11
]}

Johannesson, Magnus ^{[12
]}

Koellinger, Philipp ^{[1
,6
]}

Lee, James J. ^{[10
,13
]}

Magnusson, Patrik K. E. ^{[14
]}

Mcgue, Matt ^{[10
]}

Miller, Mike B. ^{[10
]}

Ollier, William E. R. ^{[15
]}

Payton, Antony ^{[15
]}

Pendleton, Neil ^{[16
]}

Plomin, Robert ^{[3
]}

Rietveld, Cornelius A. ^{[6
,17
]}

Tiemeier, Henning ^{[2
,11
,18
]}

van Duijn, Cornelia M. ^{[7
,19
]}

Posthuma, Danielle ^{[1
,20
]}

机构：

[1] Vrije Univ Amsterdam, Dept Complex Trait Genet, Ctr Neurogen & Cognit Res, Amsterdam Neurosci, Amsterdam, Netherlands

[2] Erasmus MC, Dept Child & Adolescent Psychiat, Rotterdam, Netherlands

[3] Kings Coll London, MRC Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England

[4] South London & Maudsley NHS Trust, NIHR Biomed Res Ctr Mental Hlth, London, England

[5] Vrije Univ Amsterdam Med Ctr, Amsterdam Neurosci, Alzheimer Ctr, Amsterdam, Netherlands

[6] Erasmus Univ, Inst Behav & Biol, Rotterdam, Netherlands

[7] Erasmus MC, Genet Epidemiol Unit, Dept Epidemiol, Rotterdam, Netherlands

[8] NYU, Dept Econ, Ctr Expt Social Sci, New York, NY 10003 USA

[9] Union Coll, Dept Psychol, Schenectady, NY 12308 USA

[10] Univ Minnesota, Dept Psychol, Minneapolis, MN USA

[11] Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

[12] Stockholm Sch Econ, Dept Econ, Stockholm, Sweden

[13] Harvard Univ, Dept Psychol, 33 Kirkland St, Cambridge, MA 02138 USA

[14] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[15] Univ Manchester, Div Populat Hlth Hlth Serv Res & Primary Care, Ctr Epidemiol, Manchester, Lancs, England

[16] Univ Manchester, Div Neurosci & Expt Psychol, Fac Biol Med & Hlth, Sch Biol Sci,Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England

[17] Erasmus Univ, Dept Appl Econ, Erasmus Sch Econ, Rotterdam, Netherlands

[18] Erasmus MC, Dept Psychiat, Rotterdam, Netherlands

[19] Leiden Univ, Translat Epidemiol, Fac Sci, Leiden, Netherlands

[20] Vrije Univ Amsterdam, Med Ctr, Dept Clin Genet, Amsterdam Neurosci, Amsterdam, Netherlands

[21] Geisinger Hlth Syst, Danville, PA USA

来源：

NATURE GENETICS | 2017年 / 49卷 / 07期

基金：

英国生物技术与生命科学研究理事会;

关键词：

LONGEVITY; INSIGHTS; TRAITS; COMMON;

D O I：

10.1038/ng.3869

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Intelligence is associated with important economic and health-related life outcomes(1). Despite intelligence having substantial heritability(2) (0.54) and a confirmed polygenic nature, initial genetic studies were mostly underpowered3-5. Here we report a meta-analysis for intelligence of 78,308 individuals. We identify 336 associated SNPs (METAL P < 5 x 10(-8)) in 18 genomic loci, of which 15 are new. Around half of the SNPs are located inside a gene, implicating 22 genes, of which 11 are new findings. Gene-based analyses identified an additional 30 genes (MAGMA P < 2.73 x 10(-6)), of which all but one had not been implicated previously. We show that the identified genes are predominantly expressed in brain tissue, and pathway analysis indicates the involvement of genes regulating cell development (MAGMA competitive P = 3.5 x 10(-6)). Despite the well-known difference in twin-based heritability2 for intelligence in childhood (0.45) and adulthood (0.80), we show substantial genetic correlation (r(g) = 0.89, LD score regression P = 5.4 x 10(-29)). These findings provide new insight into the genetic architecture of intelligence.

引用

页码：1107 / +

页数：8

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