Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

被引：13

作者：

Haneef, Zulfi ^{[1
,2
]}

Lenartowicz, Agatha ^{[3
]}

Yeh, Hsiang J. ^{[4
]}

Engel, Jerome, Jr. ^{[4
]}

Stern, John M. ^{[4
]}

机构：

[1] Baylor Coll Med, Dept Neurol, Houston, TX 77030 USA

[2] Michael E DeBakey VA Med Ctr, Neurol Care Line, Houston, TX USA

[3] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90024 USA

[4] Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90024 USA

来源：

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS | 2014年 / 90期

关键词：

Medicine; Issue; 90; Default Mode Network (DMN); Temporal Lobe Epilepsy (TLE); fMRI; MRI; functional connectivity MRI (fcMRI); blood oxygenation level dependent (BOLD); FMRI; CORTEX; DEACTIVATION; FLUCTUATIONS; ACTIVATION; PATTERNS; ROBUST; STATE;

D O I：

10.3791/51442

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Functional connectivity MRI (fcMRI) is an fMRI method that examines the connectivity of different brain areas based on the correlation of BOLD signal fluctuations over time. Temporal Lobe Epilepsy (TLE) is the most common type of adult epilepsy and involves multiple brain networks. The default mode network (DMN) is involved in conscious, resting state cognition and is thought to be affected in TLE where seizures cause impairment of consciousness. The DMN in epilepsy was examined using seed based fcMRI. The anterior and posterior hubs of the DMN were used as seeds in this analysis. The results show a disconnection between the anterior and posterior hubs of the DMN in TLE during the basal state. In addition, increased DMN connectivity to other brain regions in left TLE along with decreased connectivity in right TLE is revealed. The analysis demonstrates how seed-based fcMRI can be used to probe cerebral networks in brain disorders such as TLE.

引用

页数：7

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