Copper-catalyzed C-3 benzylation of quinoxalin-2(1H)-ones with benzylsulfonyl hydrazides

被引：8
作者：
Xie, Dong
Tian, Ren-Gui
Zhang, Xue-Ting
Tian, Shi-Kai [1 ]
机构：
[1] Univ Sci & Technol China, Hefei Natl Res Ctr Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2022年 / 20卷 / 22期
基金：
中国国家自然科学基金;
关键词：
DECARBOXYLATIVE ACYLATION; ARYLSULFONYL HYDRAZIDES; SULFONYL HYDRAZIDES; METAL; ARYLATION; TOSYLHYDRAZONES; DERIVATIVES; REAGENTS;
D O I：
10.1039/d2ob00744d
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An unprecedented use of benzylsulfonyl hydrazides as benzylating agents has been demonstrated in the direct C-3 benzylation of quinoxalin-2(1H)-ones. A range of benzylsulfonyl hydrazides participated in the C-3 benzylation of quinoxalin-2(1H)-ones with CuCN as the catalyst and DTBP as the oxidant, delivering structurally diverse 3-benzylquinoxalin-2(1H)-ones in moderate to good yields.
引用
收藏
页码：4518 / 4521
页数：4
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