Biosynthesis of medicinally important plant metabolites by unusual type III polyketide synthases

被引：24

作者：

Abe, Ikuro ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan

来源：

JOURNAL OF NATURAL MEDICINES | 2020年 / 74卷 / 04期

关键词：

Biosynthesis; Enzyme; Type III polyketide synthase; Curcumin; Quinolone; Tropane alkaloid; QUINOLONES; ALKALOIDS;

D O I：

10.1007/s11418-020-01414-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Recent research progress on the "second generation" type III polyketide synthases is summarized. This class of enzymes catalyzes unusual condensation chemistries of CoA thioesters to generate various core structures of medicinally important plant secondary metabolites, including the R-1-C-R-2 scaffold of alkyl quinolones, curcuminoids, as well as the 8-azabicyclo[3.2.1]octane ring of tropane alkaloids. The discovery of this fascinating enzyme superfamily provides excellent opportunities for the manipulation of the enzyme reactions to expand the supply of natural and unnatural molecules for future drug development.

引用

页码：639 / 646

页数：8

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