mRNA vaccines for infectious diseases: principles, delivery and clinical translation

被引：903

作者：

Chaudhary, Namit ^{[1
]}

Weissman, Drew ^{[2
]}

Whitehead, Kathryn A. ^{[1
,3
]}

机构：

[1] Carnegie Mellon Univ, Dept Chem Engn, Pittsburgh, PA 15213 USA

[2] Univ Penn, Dept Med, Philadelphia, PA 19104 USA

[3] Carnegie Mellon Univ, Dept Biomed Engn, Pittsburgh, PA 15213 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2021年 / 20卷 / 11期

基金：

美国国家卫生研究院;

关键词：

RESPIRATORY SYNCYTIAL VIRUS; LIPID NANOPARTICLE FORMULATIONS; PROOF-OF-CONCEPT; ZIKA VIRUS; PROTECTIVE EFFICACY; IN-VIVO; SYSTEMIC DELIVERY; IMMUNE-RESPONSES; T-CELLS; INTRACELLULAR DELIVERY;

D O I：

10.1038/s41573-021-00283-5

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The COVID-19 pandemic has established mRNA vaccines as a rapid, effective and safe approach for the protection of individuals from infectious disease. Here, Whitehead and colleagues review the principles of mRNA vaccine design, synthesis and delivery, assessing recent progress and key issues in the development of mRNA vaccines for a range of infectious diseases. Over the past several decades, messenger RNA (mRNA) vaccines have progressed from a scepticism-inducing idea to clinical reality. In 2020, the COVID-19 pandemic catalysed the most rapid vaccine development in history, with mRNA vaccines at the forefront of those efforts. Although it is now clear that mRNA vaccines can rapidly and safely protect patients from infectious disease, additional research is required to optimize mRNA design, intracellular delivery and applications beyond SARS-CoV-2 prophylaxis. In this Review, we describe the technologies that underlie mRNA vaccines, with an emphasis on lipid nanoparticles and other non-viral delivery vehicles. We also overview the pipeline of mRNA vaccines against various infectious disease pathogens and discuss key questions for the future application of this breakthrough vaccine platform.

引用

页码：817 / 838

页数：22

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