Exposure of vital cells to necrotic cell lysates induce the IRE1α branch of the unfolded protein response and cell proliferation

被引：5

作者：

Rohne, Philipp ^{[1
]}

Wolf, Steven ^{[1
,2
]}

Doerr, Carolin ^{[1
]}

Ringen, Julia ^{[1
]}

Holtz, Andrew ^{[1
]}

Gollan, Rene ^{[3
]}

Renner, Benjamin ^{[1
]}

Prochnow, Hans ^{[1
,4
]}

Baiersdoerfer, Markus ^{[1
]}

Koch-Brandt, Claudia ^{[1
]}

机构：

[1] Johannes Gutenberg Univ Mainz, Inst Pharm & Biochem Therapeut Life Sci, Johann Joachim Becherweg 30, D-55128 Mainz, Germany

[2] Univ Chicago, Dept Pathol, 5841 S Maryland Ave, Chicago, IL 60637 USA

[3] Johannes Gutenberg Univ Mainz, Univ Med Ctr Mainz, Dept Neurol, Mainz, Germany

[4] Helmholtz Ctr Infect Res GmbH, Dept Chem Biol, Braunschweig, Germany

来源：

CELL STRESS & CHAPERONES | 2018年 / 23卷 / 01期

关键词：

Necrosis; Clusterin; UPR; IRE1a; ERK; mTOR; XBP1; MESSENGER-RNA; CLUSTERIN GENE-EXPRESSION; ER STRESS; APOLIPOPROTEIN-J; HEAT-SHOCK; NECROSIS; DENSITY; RETROTRANSLOCATION; TRANSCRIPTION; INFLAMMATION;

D O I：

10.1007/s12192-017-0825-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Necrosis is a form of cell death that is detrimental to the affected tissue because the cell ruptures and releases its content (reactive oxygen species among others) into the extracellular space. Clusterin (CLU), a cytoprotective extracellular chaperone has been shown to be upregulated in the face of necrosis. We here show that in addition to CLU upregulation, necrotic cell lysates induce JNK/SAPK signaling, the IRE1 alpha branch of the unfolded protein response (UPR), the MAPK/ERK1/2, and the mTOR signaling pathways and results in an enhanced proliferation of the vital surrounding cells. We name this novel response mechanism: Necrosis-induced Proliferation (NiP).

引用

页码：77 / 88

页数：12

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