Potential Health Risks Linked to Emerging Contaminants in Major Rivers and Treated Waters

被引:8
作者
Kessler, James [1 ]
Dawley, Diane [2 ]
Crow, Daniel [2 ]
Garmany, Ramin [1 ]
Georgel, Philippe T. [1 ,3 ]
机构
[1] Marshall Univ, Dept Biol Sci, Huntington, WV 25755 USA
[2] Marshall Univ, Joan C Edwards Sch Med, Huntington, WV 25755 USA
[3] Marshall Univ, Dept Biol Sci, Coll Sci, Cell Differentiat & Dev Ctr, Huntington, WV 25755 USA
基金
美国国家科学基金会;
关键词
endocrine disrupting chemical; opioid; pathway analysis; ontology; metabolomics; ENDOCRINE-DISRUPTING CHEMICALS; BISPHENOL-A EXPOSURE; BREAST-CANCER; ATRAZINE EXPOSURE; OXIDATIVE STRESS; DRINKING-WATER; WASTE-WATER; BEHAVIORAL ALTERATIONS; PRENATAL EXPOSURE; DRUG CONSUMPTION;
D O I
10.3390/w11122615
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
The presence of endocrine-disrupting chemicals (EDCs) in our local waterways is becoming an increasing threat to the surrounding population. These compounds and their degradation products (found in pesticides, herbicides, and plastic waste) are known to interfere with a range of biological functions from reproduction to differentiation. To better understand these effects, we used an in silico ontological pathway analysis to identify the genes affected by the most commonly detected EDCs in large river water supplies, which we grouped together based on four common functions: Organismal injuries, cell death, cancer, and behavior. In addition to EDCs, we included the opioid buprenorphine in our study, as this similar ecological threat has become increasingly detected in river water supplies. Through the identification of the pleiotropic biological effects associated with both the acute and chronic exposure to EDCs and opioids in local water supplies, our results highlight a serious health threat worthy of additional investigations with a potential emphasis on the effects linked to increased DNA damage.
引用
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页数:32
相关论文
共 148 条
[1]   Neonatal Bisphenol-A Exposure Alters Rat Reproductive Development and Ovarian Morphology Without Impairing Activation of Gonadotropin-Releasing Hormone Neurons [J].
Adewale, Heather B. ;
Jefferson, Wendy N. ;
Newbold, Retha R. ;
Patisaul, Heather B. .
BIOLOGY OF REPRODUCTION, 2009, 81 (04) :690-699
[2]  
Ahangarpour A, 2016, J PHYSIOL PHARMACOL, V67, P243
[3]   Endosulfan-Induced Apoptosis and Glutathione Depletion in Human Peripheral Blood Mononuclear Cells: Attenuation by N-Acetylcysteine [J].
Ahmed, Tanzeel ;
Tripathi, Ashok K. ;
Ahmed, Rafat S. ;
Das, Shukla ;
Suke, Sanvidhan G. ;
Pathak, Rahul ;
Chakraboti, Ayanabha ;
Banerjee, Basu Dev .
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2008, 22 (05) :299-304
[4]   An Alkylphenol Mix Promotes Seminoma Derived Cell Proliferation through an ERalpha36-Mediated Mechanism [J].
Ajj, Hussein ;
Chesnel, Amand ;
Pinel, Sophie ;
Plenat, Francois ;
Flament, Stephane ;
Dumond, Helene .
PLOS ONE, 2013, 8 (04)
[5]   Increased Cancer Burden Among Pesticide Applicators and Others Due to Pesticide Exposure [J].
Alavanja, Michael C. R. ;
Ross, Matthew K. ;
Bonner, Matthew R. .
CA-A CANCER JOURNAL FOR CLINICIANS, 2013, 63 (02) :120-142
[6]   Bisphenol-A exposure alters endometrial progesterone receptor expression in the nonhuman primate [J].
Aldad, Tamir S. ;
Rahmani, Nora ;
Leranth, Csaba ;
Taylor, Hugh S. .
FERTILITY AND STERILITY, 2011, 96 (01) :175-179
[7]   Striatal dopamine D1 and D2 receptors are differentially regulated following buprenorphine or methadone treatment [J].
Allouche, Stephane ;
Le Marec, Thierry ;
Coquerel, Antoine ;
Noble, Florence ;
Marie, Nicolas .
PSYCHOPHARMACOLOGY, 2015, 232 (09) :1527-1533
[8]   Cytogenetic damage in peripheral blood lymphocytes of children exposed to pesticides in agricultural areas of the department of Cordoba, Colombia [J].
Alonso Ruiz-Guzman, Javier ;
Gomez-Corrales, Pamela ;
Cruz-Esquivel, Angel ;
Luis Marrugo-Negrete, Jose .
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2017, 824 :25-31
[9]   Early postnatal exposure to endosulfan interferes with the normal development of the male rat mammary gland [J].
Altamirano, Gabriela A. ;
Delconte, Melisa B. ;
Gomez, Ayelen L. ;
Alarcon, Ramiro ;
Bosquiazzo, Veronica L. ;
Luque, Enrique H. ;
Munoz-de-Toro, Monica ;
Kass, Laura .
TOXICOLOGY LETTERS, 2017, 281 :102-109
[10]   Endocrine Disruptor Agent Nonyl Phenol Exerts An Estrogen-like Transcriptional Activity on Estrogen Receptor Positive Breast Cancer Cells [J].
Amaro, A. A. ;
Esposito, A. I. ;
Mirisola, V. ;
Mehilli, A. ;
Rosano, C. ;
Noonan, D. M. ;
Albini, A. ;
Pfeffer, U. ;
Angelini, G. .
CURRENT MEDICINAL CHEMISTRY, 2014, 21 (05) :630-640