From binge eating to binge drinking: A new and robust paradigm for assessing binge ethanol self-administration in male rats

被引:3
作者
Ruiz-Leyva, Leandro [1 ,2 ]
Vazquez-Agredos, Ana [3 ]
Jimenez-Garcia, Ana M. [4 ]
Lopez-Guarnido, Olga [5 ]
Pla, Antonio [5 ,6 ]
Marcos Pautassi, Ricardo [7 ,8 ]
Moron Henche, Ignacio [9 ,10 ]
Miguel Cendan, Cruz [1 ,2 ]
机构
[1] Univ Granada, Biomed Res Ctr CIBM, Inst Neurosci, Dept Pharmacol,Fac Med, Granada, Spain
[2] Univ Granada, Biomed Res Ctr CIBM, Inst Neurosci, Dept Psychobiol, Granada, Spain
[3] Inst Invest Biosanitaria IBS, Granada, Spain
[4] Univ Nebrija, Fac Life Sci & Nat, Dept Psychol, Hoyo De Manzanares, Spain
[5] Univ Granada, Fac Med, Dept Legal Med & Toxicol, Granada, Spain
[6] Hosp Univ Clin San Cecilio, Granada, Spain
[7] Univ Nacl Cordoba, Inst Invest Med M&M Ferreyra, INIMEC CONICET UNC, INIMEC CONICET, Cordoba, Argentina
[8] UNC, Fac Psicol, Cordoba, Argentina
[9] Univ Granada, Fac Psychol, Dept Psychobiol, Granada, Spain
[10] Univ Granada, Fac Psychol, Ctr Invest Mind Brain & Behav CIMCYC, Granada, Spain
关键词
binge drinking; binge eating; ethanol; naltrexone; self-administration; ALCOHOL-DRINKING; INTERMITTENT ACCESS; ANIMAL-MODELS; CONSUMPTION; SCHEDULE; MEDICATIONS; NALTREXONE; POLYDIPSIA; DEPENDENCE; DOPAMINE;
D O I
10.1111/adb.13153
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Animal models of alcohol (ethanol) self-administration are crucial to dissect the neurobiological mechanisms underlying alcohol dependence, yet only a few of these induce pharmacologically relevant levels of alcohol consumption and rarely the alcohol self-administration co-occurs with other addictive behaviours. The present study aims to validate a novel model of voluntary ethanol consumption in male Wistar rats, in which ethanol access follows a binge eating experience. Over 10 sessions, Wistar rats were exposed to binge or control eating (i.e., the ingestion of 11.66 and 0.97 kcal/3 min, respectively, derived from a highly palatable food), immediately followed by two-bottle choice intake tests (2%, 6%, 10% or 14% w/w ethanol vs. water). Rats exposed to binge eating drank significantly more 6% or 10% (w/w) ethanol than control peers, reaching up to 6.3 g(EtOH)/kg. Rats stimulated with 2%, 6%, 10% or 14% ethanol after binge eating, but not those given those ethanol concentrations after control eating, exhibited significant within-group increases in ethanol drinking. This ethanol consumption was not altered by quinine adulteration (up to 0.1 g/L), and it was blocked by naltrexone (10 mg/kg), administered immediately before binge eating. Blood ethanol levels significantly correlated with ethanol consumption; and the more ethanol consumed, the greater the distance travelled in an open field test conducted after the two-bottle choice test. Altogether, this self-administration model seems a valid and robust alternative with remarkable potential for research on different stages of the alcohol addiction and, particularly, to assess interactions between alcohol consumption and others addictive-like behaviours.
引用
收藏
页数:11
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