Nephrotoxicity of contrast media and protective effects of acetylcysteine

被引：38
作者：
Briguori, Carlo [1 ]
Quintavalle, Cristina [2 ,3 ]
De Micco, Francesca [4 ]
Condorelli, Gerolama [5 ]
机构：
[1] Clin Mediterranea, Lab Intervent Cardiol, I-80121 Naples, Italy
[2] Univ Naples Federico II, Dept Cellular & Mol Biol & Pathol, I-80121 Naples, Italy
[3] Univ Naples Federico II, CNR, IEOS, I-80121 Naples, Italy
[4] IRCCS Multimed, Milan, Italy
[5] Fdn SDN, I-80121 Naples, Italy
来源：
ARCHIVES OF TOXICOLOGY | 2011年 / 85卷 / 03期
关键词：
Kidney; Contrast media; NAC; Apoptosis; Acetylcysteine; RANDOMIZED CONTROLLED-TRIAL; RADIOCONTRAST-INDUCED NEPHROPATHY; AGENT-ASSOCIATED NEPHROTOXICITY; OXYGEN-FREE-RADICALS; ACUTE KIDNEY INJURY; N-ACETYL CYSTEINE; CELLS IN-VITRO; CORONARY-ANGIOGRAPHY; RENAL-FUNCTION; CARDIAC-CATHETERIZATION;
D O I：
10.1007/s00204-010-0626-5
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Contrast-induced acute kidney injury (CI-AKI) accounts for approximately 10% of all causes of hospital-acquired renal failure, causes a prolonged in-hospital stay, and represents a powerful predictor of poor early and late outcome. N-acetylcysteine (NAC) is a thiol compound classically known as a mucolytic agent, which is a potent antioxidant that scavenges a wide variety of oxygen-derived-free-radicals and may be capable of preventing acute kidney injury. In the present study, we will review (1) the pathophysiology of the CI-AKI and (2) the experimental and clinical data on the effects of NAC in preventing CI-AKI.
引用
收藏
页码：165 / 173
页数：9
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