A systematic review on the role of MSC-derived exosomal miRNAs in the treatment of heart failure

被引：8

作者：

Botello-Flores, Yesica Abril ^{[1
,2
]}

Yocupicio-Monroy, Martha ^{[2
]}

Balderrabano-Saucedo, Norma ^{[3
]}

Contreras-Ramos, Alejandra ^{[1
]}

机构：

[1] Childrens Hosp Mexico Federico Gomez HIMFG, Lab Dev Biol Res & Expt Teratogen, Dr Marquez 162, Mexico City 06720, DF, Mexico

[2] Autonomous Univ Mexico City, Postgrad Genom Sci, Mexico City, DF, Mexico

[3] Childrens Hosp Mexico Federico Gomez HIMFG, Res Lab Cardiomyopathies & Arrhythmias, Mexico City, DF, Mexico

来源：

MOLECULAR BIOLOGY REPORTS | 2022年 / 49卷 / 09期

关键词：

Systematic review; Heart failure; Heart diseases; Biomarkers; miRNAs; MSCs; Exosomal; MESENCHYMAL STEM-CELLS; ACUTE MYOCARDIAL-INFARCTION; HUMAN ADIPOSE-TISSUE; SIGNAL TRANSDUCER; REPERFUSION INJURY; OXIDATIVE STRESS; ACTIVATOR; CARDIOMYOCYTES; APOPTOSIS; CARDIOMYOPATHY;

D O I：

10.1007/s11033-022-07385-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background This systematic review summarizes results of studies that evaluated the expression of microRNAs (miRs) in pre-diabetes or type 2 diabetes. Methods The information was obtained in PubMed, EMBL-EBI, Wanfang, Trip Database, Lilacs, CINAHL and Google. A qualitative synthesis of the results was performed and miRs frequency was graphically. From 1880 we identified studies, only 53 fulfilled the inclusion criteria. The 53 studies analyzed miRs in T2D; and of them, thirteen also described data in pre-diabetes. Results In diabetics, 122 miRs were reported and 35 miRs for pre-diabetics. However, we identified that 5 miRs (-122-5p, 144-3p, 210, 375, -126b) were reported more often in diabetics, and 4 (144-3p, -192, 29a and -30d) in pre-diabetics. Conclusions Circulating miRs could be used as biomarkers of type 2 diabetes. However, it is necessary to validate these microRNAs in prospective and multi-center studies, where different population subgroups, considering the age, gender, and risk factors.

引用

页码：8953 / 8973

页数：21

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