Calcium and Magnesium Prophylaxis for Oxaliplatin-Related Neurotoxicity: Is It a Trade-off Between Drug Efficacy and Toxicity?

被引：13
作者：
Cavaletti, Guido [1 ]
机构：
[1] Univ Milano Bicocca, Dept Neurosci & Biomed Technol, I-20900 Monza, MI, Italy
来源：
ONCOLOGIST | 2011年 / 16卷 / 12期
关键词：
INDUCED PERIPHERAL NEUROPATHY; METASTATIC COLORECTAL-CANCER; SEVERITY;
D O I：
10.1634/theoncologist.2011-0343
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Oxaliplatin-based chemotherapy regimens are the current standard treatment in the management of colorectal cancer. Neurotoxicity is the major cause of treatment delay, dose reduction, and cessation of oxaliplatin. Evidence regarding the role of calcium and magnesium prophylaxis to prevent oxaliplatin-related neurotoxicity is conflicting and further randomized data are needed to answer this question accurately. The purpose of this paper is to provide a critical overview of various studies that have been conducted so far to evaluate the preventative role of calcium and magnesium prophylaxis against oxaliplatin-related neurotoxicity. The Oncologist 2011;16:1780-1783
引用
收藏
页码：1667 / 1668
页数：2
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