Formation of cyclic dimers of IgE-Fc epsilon RI complexes by a symmetrical bivalent ligand results in tyrosine phosphorylation of the gamma subunit but not the beta subunit of Fc epsilon RI and fails to activate p72(Syk) or cellular degranulation.

被引：0
|
作者：
Troy, NT [1 ]
Holowka, D [1 ]
Baird, B [1 ]
机构：
[1] CORNELL UNIV,DEPT CHEM,ITHACA,NY 14853
来源：
FASEB JOURNAL | 1996年 / 10卷 / 06期
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：1247 / 1247
页数：1
相关论文
共 3 条
  • [1] Altered patterns of tyrosine phosphorylation and Syk activation for sterically restricted cyclic dimers of IgE-Fc epsilon RI
    Harris, NT
    Goldstein, B
    Holowka, D
    Baird, B
    BIOCHEMISTRY, 1997, 36 (08) : 2237 - 2242
  • [2] INTERACTION OF P72(SYK) WITH THE GAMMA-SUBUNITS AND BETA-SUBUNITS OF THE HIGH-AFFINITY RECEPTOR FOR IMMUNOGLOBULIN-E, IMMUNOGLOBULIN-FC-EPSILON-RI
    SHIUE, L
    GREEN, J
    GREEN, OM
    KARAS, JL
    MORGENSTERN, JP
    RAM, MK
    TAYLOR, MK
    ZOLLER, MJ
    ZYDOWSKY, LD
    BOLEN, JB
    BRUGGE, JS
    MOLECULAR AND CELLULAR BIOLOGY, 1995, 15 (01) : 272 - 281
  • [3] Interaction of phosphorylated Fc epsilon RI gamma immunoglobulin receptor tyrosine activation motif-based peptides with dual and single SH2 domains of p72(syk) - Assessment of binding parameters and real, time binding kinetics
    Chen, T
    Repetto, B
    Chizzonite, R
    Pullar, C
    Burghardt, C
    Dharm, E
    Zhao, AC
    Carroll, R
    Nunes, P
    Basu, M
    Danho, W
    Visnick, M
    Kochan, J
    Waugh, D
    Gilfillan, AM
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (41) : 25308 - 25315
1