Meta-analysis of cortical thickness abnormalities in medication-free patients with major depressive disorder

被引:113
作者
Li, Qian [1 ,2 ]
Zhao, Youjin [1 ,2 ]
Chen, Ziqi [1 ,2 ]
Long, Jingyi [1 ,2 ]
Dai, Jing [3 ]
Huang, Xiaoqi [1 ,2 ]
Lui, Su [1 ,2 ]
Radua, Joaquim [4 ,5 ,6 ]
Vieta, Eduard [4 ,7 ]
Kemp, Graham J. [8 ,9 ]
Sweeney, John A. [1 ,10 ]
Li, Fei [1 ,2 ]
Gong, Qiyong [1 ,2 ]
机构
[1] Sichuan Univ, Funct & Mol Imaging Key Lab Sichuan, Huaxi MR Res Ctr HMRRC, Dept Radiol,West China Hosp, Chengdu 610041, Sichuan, Peoples R China
[2] Sichuan Univ, Psychoradiol Res Unit, Chinese Acad Med Sci 2018RU011, West China Hosp, Chengdu 610041, Peoples R China
[3] Fourth Peoples Hosp Chengdu, Dept Psychoradiol, Chengdu, Peoples R China
[4] Inst Invest Biomed August Pi & Sunyer IDIBAPS, Mental Hlth Res Networking Ctr CIBERSAM, Barcelona, Spain
[5] Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res & Educ, Stockholm, Sweden
[6] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England
[7] Univ Barcelona, Inst Neurosci, Hosp Clin, Barcelona Bipolar Disorders & Depress Unit, Barcelona, Spain
[8] Univ Liverpool, Liverpool Magnet Resonance Imaging Ctr LiMRIC, Liverpool, Merseyside, England
[9] Univ Liverpool, Inst Ageing & Chron Dis, Liverpool, Merseyside, England
[10] Univ Cincinnati, Dept Psychiat, Cincinnati, OH USA
关键词
HUMAN CEREBRAL-CORTEX; WHITE-MATTER; ORBITOFRONTAL CORTEX; SUBCORTICAL VOLUME; CINGULATE CORTEX; 1ST EPISODE; DRUG-NAIVE; CONNECTIVITY; NETWORK; SCHIZOPHRENIA;
D O I
10.1038/s41386-019-0563-9
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Alterations in cortical thickness have been identified in major depressive disorder (MDD), but findings have been variable and inconsistent. To date, no reliable tools have been available for the meta-analysis of surface-based morphometric (SBM) studies to effectively characterize what has been learned in previous studies, and drug treatments may have differentially impacted findings. We conducted a comprehensive meta-analysis of magnetic resonance imaging (MRI) studies that explored cortical thickness in medication-free patients with MDD, using a newly developed meta-analytic mask compatible with seed-based d mapping (SDM) meta-analytic software. We performed the meta-regression to explore the effects of demographics and clinical characteristics on variation in cortical thickness in MDD. Fifteen studies describing 529 patients and 586 healthy controls (HCs) were included. Medication-free patients with MDD, relative to HCs, showed a complex pattern of increased cortical thickness in some areas (posterior cingulate cortex, ventromedial prefrontal cortex, and anterior cingulate cortex) and decreased cortical thickness in others (gyrus rectus, orbital segment of the superior frontal gyrus, and middle temporal gyrus). Most findings in the whole sample analysis were confirmed in a meta-analysis of studies recruiting medication-naive patients. Using the new mask specifically developed for SBM studies, this SDM meta-analysis provides evidence for regional cortical thickness alterations in MDD, mainly involving increased cortical thickness in the default mode network and decreased cortical thickness in the orbitofrontal and temporal cortex.
引用
收藏
页码:703 / 712
页数:10
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