Noncytotoxic Roles of Granzymes in Health and Disease

被引：7

作者：

Richardson, Katlyn C. ^{[1
,2
]}

Jung, Karen ^{[1
,2
]}

Pardo, Julian ^{[3
,4
,5
]}

Turner, Christopher T. ^{[6
,7
]}

Granville, David J. ^{[1
,2
]}

机构：

[1] Vancouver Coastal Hlth Res Inst, British Columbia Profess Firefighters Wound Heali, Int Collaborat Repair Discoveries ICORD, Vancouver, BC, Canada

[2] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC, Canada

[3] Biomed Res Ctr Aragon CIBA, Fdn Inst Invest Sanitaria Aragon IIS Aragon, Zaragoza, Spain

[4] Univ Zaragoza, Dept Microbiol Radiol Pediat & Publ Hlth, Zaragoza, Spain

[5] Inst Salud Carlos III, CIBER Enfermedades Infecciosas, Zaragoza, Spain

[6] Monash Univ, Fac Pharm & Pharmaceut Sci, Melbourne, Vic, Australia

[7] Univ South Australia, Future Ind Inst, Adelaide, SA, Australia

来源：

PHYSIOLOGY | 2022年 / 37卷 / 06期

基金：

加拿大健康研究院;

关键词：

barrier dysfunction; granzymes; inflammation; serine proteases; wound healing; SERINE-PROTEASE GRANZYME; CYTOTOXIC T-LYMPHOCYTES; CYTOCHROME-C RELEASE; MYELIN BASIC-PROTEIN; SOLUBLE E-CADHERIN; EXTRACELLULAR-MATRIX; B-CELLS; MOUSE GRANZYME; NK-CELL; HUMAN KERATINOCYTES;

D O I：

10.1152/physiol.00011.2022

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Granzymes are serine proteases previously believed to play exclusive and somewhat redundant roles in lymphocyte-mediated target cell death. However, recent studies have challenged this paradigm. Distinct substrate profiles and functions have since emerged for each granzyme while their dysregulated proteolytic activities have been linked to diverse pathologies.

引用

页码：323 / 348

页数：26

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