Condensed thiazoles .2. Synthesis of 7-substituted thiazolo[4,5-d]pyrimidines as possible anti-HIV, anticancer, and antimicrobial agents

被引：11

作者：

Habib, NS

Rida, SM

Badawey, EAM

Fahmy, HTY

机构：

[1] Dept. of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria

来源：

MONATSHEFTE FUR CHEMIE | 1996年 / 127卷 / 11期

关键词：

4-amino-5-carbamoylthiazoles; thiazolo[4,5-d]pyrimidines;

D O I：

10.1007/BF00844697

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Some 3-substituted 2-thioxothiazolo[4,5-d]pyrimidin-7(6H)-ones (2a, b; 4) have been synthesized and converted to their 7-chloro (3, 5), 7-diethanolamino (6a,b), 7-bis(2-chloroethyl)amino (7), 7-azido (8), 7-amino (9), 7-hydrazino (10), 7-mercapto (11a, b), and 7-methylthio (12) derivatives. These compounds were evaluated for their in vitro antimicrobial, anti-HIV, and anticancer activities.

引用

页码：1209 / 1214

页数：6

共 18 条

[1] POTENTIAL ANTI-MICROBIALS .1. SYNTHESIS AND STRUCTURE-ACTIVITY STUDIES OF SOME NEW THIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES [J].