Ultraviolet radiation-induced DNA damage is prognostic for outcome in melanoma

被引：75

作者：

Trucco, Lucas D. ^{[1
]}

Mundra, Piyushkumar A. ^{[1
]}

Hogan, Kate ^{[1
]}

Garcia-Martinez, Pablo ^{[1
]}

Viros, Amaya ^{[1
]}

Mandal, Amit K. ^{[1
]}

Macagno, Nicolas ^{[2
]}

Gaudy-Marqueste, Caroline ^{[3
]}

Allan, Donald ^{[4
,5
]}

Baenke, Franziska ^{[1
]}

Cook, Martin ^{[1
]}

McManus, Clare ^{[1
]}

Sanchez-Laorden, Berta ^{[1
]}

Dhomen, Nathalie ^{[1
]}

Marais, Richard ^{[1
]}

机构：

[1] Univ Manchester, Canc Res UK Manchester Inst, Mol Oncol Grp, Manchester, Lancs, England

[2] Aix Marseille Univ, Hop Timone, APHM, Dept Pathol, Marseille, France

[3] Aix Marseille Univ, Hop Timone, APHM, Dermatol & Skin Canc Dept, Marseille, France

[4] Univ Manchester, Med Phys Dept, Manchester Acad Hlth Sci Ctr, Salford Royal NHS Fdn Trust, Salford, Lancs, England

[5] Univ Manchester, Salford Royal NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Salford, Lancs, England

来源：

NATURE MEDICINE | 2019年 / 25卷 / 02期

基金：

欧洲研究理事会;

关键词：

MUTATIONAL PROCESSES;

D O I：

10.1038/s41591-018-0265-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The melanoma genome is dominated by ultraviolet radiation (UVR)-induced mutations. Their relevance in disease progression is unknown. Here we classify melanomas by mutation signatures and identify ten recurrently mutated UVR signature genes that predict patient survival. We validate these findings in primary human melanomas; in mice we show that this signature is imprinted by short-wavelength UVR and that four exposures to UVR are sufficient to accelerate melanomagenesis.

引用

页码：221 / +

页数：14

共 50 条

[1] Ultraviolet radiation–induced DNA damage is prognostic for outcome in melanoma
Lucas D. Trucco
Piyushkumar A. Mundra
Kate Hogan
Pablo Garcia-Martinez
Amaya Viros
Amit K. Mandal
Nicolas Macagno
Caroline Gaudy-Marqueste
Donald Allan
Franziska Baenke
Martin Cook
Clare McManus
Berta Sanchez-Laorden
Nathalie Dhomen
Richard Marais
Nature Medicine, 2019, 25 : 221 - 224
[2] Vemurafenib impairs the repair of ultraviolet radiation-induced DNA damage
Kimeswenger, Susanne
Mann, Ulrike
Hoeller, Christoph
Foedinger, Dagmar
Jantschitsch, Christian
MELANOMA RESEARCH, 2019, 29 (02) : 134 - 144
[3] Sunscreens decrease ultraviolet radiation-induced DNA damage repair
Costlow, ME
Anthony, FA
Hood, DK
Learn, DB
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1996, 106 (04) : 373 - 373
[4] Molecular Mechanisms of Ultraviolet Radiation-Induced DNA Damage and Repair
Rastogi, Rajesh P.
Richa
Kumar, Ashok
Tyagi, Madhu B.
Sinha, Rajeshwar P.
JOURNAL OF NUCLEIC ACIDS, 2010, 2010
[5] Ultraviolet radiation-induced non-melanoma skin cancer: Regulation of DNA damage repair and inflammation
Kim, InYoung
He, Yu-Ying
GENES & DISEASES, 2014, 1 (02) : 188 - 198
[6] Histidinemic mice are hypersensitive to ultraviolet B radiation-induced DNA damage
Eckhart, Leopold
Barresi, Caterina
Stremnitzer, Caroline
Mlitz, Veronika
Zhang, Haiping
Tschachler, Erwin
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2010, 130 : S49 - S49
[7] Measuring vacuum ultraviolet radiation-induced damage
Lauer, JL
Shohet, JL
Hansen, RW
JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A, 2003, 21 (04): : 1253 - 1259
[8] ULTRAVIOLET RADIATION-INDUCED DNA DAMAGE AND ITS PHOTOREPAIR IN THE SKIN OF THE PLATYFISH XIPHOPHORUS
AHMED, FE
SETLOW, RB
CANCER RESEARCH, 1993, 53 (10) : 2249 - 2255
[9] Regulation of ultraviolet radiation-induced cutaneous DNA damage by type I interferons
Sherwani, Mohammad Asif
Ahmad, Israr
Raman, Chander
Elmets, Craig
Yusuf, Nabiha
JOURNAL OF IMMUNOLOGY, 2020, 204 (01):
[10] Nicotinamide enhances repair of ultraviolet radiation-induced DNA damage in primary melanocytes
Thompson, Benjamin C.
Surjana, Devita
Halliday, Gary M.
Damian, Diona L.
EXPERIMENTAL DERMATOLOGY, 2014, 23 (07) : 509 - 511

← 1 2 3 4 5 →