Cyclodextrin-based metal-organic framework nanoparticles as superior carriers for curcumin: Study of encapsulation mechanism, solubility, release kinetics, and antioxidative stability

被引：68

作者：

Chen, Yulu ^{[1
]}

Su, Jiaqi ^{[1
,2
]}

Dong, Wenxia ^{[1
]}

Xu, Duoxia ^{[3
]}

Cheng, Lei ^{[3
]}

Mao, Like ^{[1
]}

Gao, Yanxiang ^{[1
]}

Yuan, Fang ^{[1
]}

机构：

[1] China Agr Univ, Coll Food Sci & Nutr Engn, Key Lab Precis Nutr & Food Qual, Key Lab Funct Dairy,Minist Educ, Beijing 100083, Peoples R China

[2] Univ Ghent, Fac Biosci Engn, Particle & Interfacial Technol Grp, Coupure Links 653, B-9000 Ghent, Belgium

[3] Beijing Technol & Business Univ, Beijing Engn & Technol Res Ctr Food Addit, Beijing 100048, Peoples R China

来源：

FOOD CHEMISTRY | 2022年 / 383卷

关键词：

Encapsulation technology; Cyclodextrin; Metal-organic frameworks; Nanoparticles; Curcumin; Solubility enhancement; GAMMA-CYCLODEXTRIN; PARTICLES; DELIVERY; RAMAN;

D O I：

10.1016/j.foodchem.2022.132605

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In this paper, we propose a facile program of preparing nanoscale gamma-cyclodextrin-based metal-organic frameworks (Nano-CD-MOFs) for the encapsulation of curcumin. Such Nano-CD-MOFs not only possess excellent mono-dispersity and crystalline structure, but also perform superior loading capacity. The results of N2 adsorption-desorption, XRD, DSC, and microtopography are utilized to confirm the presence status of encapsulated curcumin and further reveal the encapsulation mechanism of Nano-CD-MOFs. Curcumin-loaded NanoCD-MOFs (Cur-Nano-CD-MOFs) dramatically increase curcumin solubility and a top-down uniform dispersion in the dissolution process. The perfect fitting of First-order and Korsmeyer-Peppas models suggests that the release performance of Nano-CD-MOFs is controlled by the loaded quantity of curcumin and related to Fickian diffusion. Moreover, the antioxidative stability of Cur-Nano-CD-MOFs is considerably enhanced even after 120 min of persistent ultraviolet irradiation. Therefore, we suggest that such Nano-CD-MOFs can be promoted as an advanced carrier for the delivery of curcumin or other nutraceuticals.

引用

页数：11

共 40 条

[11] Methodologies for simulation of gastrointestinal digestion of different controlled delivery systems and further uptake of encapsulated bioactive compounds [J].